Drug Delivery for Neuromuscular Blockade With Supervised Multimodel Adaptive Control

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Teresa Mendonca (Author) FCUP; Joao M Lemos (Author) Other; Hugo Magalhaes (Author) Other; Paula Rocha (Author) FEUP; Simao Esteves (Author) Other

Journal

Title: IEEE Transactions on Control Systems Technology

Vol. 17 No. 5

Pages: 1237-1244

ISSN: 1063-6536

Publisher: IEEE

Indexing

ISI Web of Knowledge - 47 Citations

ISI Web of Science

Scopus - 58 Citations

Scientific classification

FOS: Engineering and technology > Electrical engineering, Electronic engineering, Information engineering

Other information

Authenticus ID: P-003-ENK

DOI: 10.1109/tcst.2008.2005995

Abstract (EN): A major issue in drug delivery systems is the high level of uncertainty due to inter- and intrapatient variations in the dynamics of drug absorption and metabolism. This paper proposes an approach to tackle this problem based on supervised multi-model adaptive control (SMMAC). Although the specific case of neuromuscular-blockade-level control of patients subject to general anesthesia is considered, the overall procedure can be applied to the control of other physiological variables. Design guidelines to implement SMMAC are presented, together with clinical cases of patients undergoing general anesthesia, where atracurium is used as the blocking agent. The important role played by the selection of the observer polynomial in the supervisor is demonstrated.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8