Decrease of E-Cadherin Expression in Canine Cutaneous Histiocytoma Appears to be Related to its Spontaneous Regression

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Pires, I (Author) Other; Queiroga, FL (Author) Other; Alves, A (Author) Other; Silva, F (Author) Other; Lopes, C (Author) ICBAS

Journal

Title: Anticancer Research

Vol. 29

Pages: 2713-2717

ISSN: 0250-7005

Publisher: International Institute of Anticancer Research

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 18 Citations

Other information

Authenticus ID: P-003-HKW

Abstract (EN): Background: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. Materials and Methods: E-cadherin immuno-expression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. Results: All tumours expressed membranous E-cadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed. However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001). Conclusion: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression. The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5