Karyotypic divergence and convergence in two synchronous lung metastases of a clear cell sarcoma of tendons and aponeuroses with t(12;22)(q13;q12) and type 1 EWS/ATF1

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Manuel R Teixeira (Author) ICBAS; Ribeiro, FR (Author) Other; cerveira, n (Author) Other; Torres, L (Author) Other; Amaro, T (Author) Other; henrique, rmf (Author) ICBAS; Lopes, C (Author) ICBAS

Journal

Title: Cancer Genetics and Cytogenetics

Vol. 145

Pages: 121-125

ISSN: 0165-4608

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-000-F7X

DOI: 10.1016/s0165-4608(03)00063-3

Abstract (EN): Clear cell sarcoma of tendons and aponeuroses (CCS) is an uncommon malignancy characterized by a t(12;22)(q13;q12) causing a fusion of the EWS and ATFl genes. We describe the cytogenetic and molecular genetic analyses of two lung metastases from a CCS patient. Both lesions presented the defining t(l 2;22) and a type I EWS/ATFl chimeric transcript. The additional cytogenetic changes present in the two lesions allowed us to obtain some insight into the pathogenetic basis of disease progression. Four related clones were identified in the right lung metastasis, permitting a partial reconstitution of the stepwise clonal evolution, whereas the left lung metastasis presented yet another subclone. The comparison of the two karyotypes enabled us to pinpoint which changes occurred in the primary tumor and which emerged independently after the two metastases had been established. We conclude that both clonal divergence and convergence may be operative during tumor progression of CCS.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5