COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary cancer

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Queiroga, FL (Author) Other; Pires, I (Author) Other; Parente, M (Author) Other; Gregorio, H (Author) Other; Lopes, C (Author) ICBAS

Journal

Title: Veterinary Journal

Vol. 189

Pages: 77-82

ISSN: 1090-0233

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 36 Citations

Scopus - 47 Citations

Other information

Authenticus ID: P-002-Q0V

DOI: 10.1016/j.tvjl.2010.06.022

Abstract (EN): This study was designed to investigate the possible roles of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in canine mammary cancer angiogenesis. Immunohistochemistry was performed on 70 tumours (28 benign and 42 malignant) in order to detect COX-2 and VEGF expression. Microvessel density (MVD) was determined by CD31 immunolabelling to assess tumour angiogenesis. There was a significantly higher expression of COX-2 (P < 0.001), VEGF (P < 0.001) and MVD (P < 0.001) in malignant compared to benign tumours. In the malignant group, the MVD of COX-2 positive tumours was significantly higher than that of COX-2 negative tumours (P = 0.026). A similar association was observed for VEGF (P < 0.001) positive tumours. The results from this study suggested that over-expression of COX-2 and VEGF may contribute to increased angiogenesis and aggression in malignant tumours.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6