Cox-2 levels in canine mammary tumors, including inflammatory mammary carcinoma: Clinicopathological features and prognostic significance

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Queiroga, FL (Author) Other; Perez Alenza, MD (Author) Other; Silvan, G (Author) Other; Pena, L (Author) Other; Lopes, C (Author) ICBAS; Illera, JC (Author) Other

Journal

Title: Anticancer Research

Vol. 25

Pages: 4269-4275

ISSN: 0250-7005

Publisher: International Institute of Anticancer Research

Indexing

ISI Web of Knowledge - 43 Citations

Scopus - 49 Citations

Other information

Authenticus ID: P-000-0JJ

Abstract (EN): Cyclo-oxygenase (Cox-2) plays an important role in mammary carcinogenesis, nevertheless, its role in canine mammary tumors, and particularly in inflammatory mammary carcinoma (IMC), is unknown. Tumor Cox-2 levels were analyzed by enzyme immunoassay, in post-surgical tumor homogenates of 129 mammary tumors (62 dysplasias and benign tumors, 57 malignant non-IMC and 10 IMC) from 57 female dogs. The highest Cox-2 values were detected in the IMC group. In non-1MC malignant tumors, high values of Cox-2 were related to skin ulceration (p<0.001) and tumor size (p <0. 001). The follow-up study revealed that high Cox-2 levels were related with recurrence (p=0.002), metastases (p<0.001), disease-free survival (p<0.001) and overall survival (p<0.001). This study demonstrates an association between intra-tumor Cox-2 levels and poor prognosis. The high levels found in IMC cases could indicate a special role of Cox2 in the inflammatory phenotype and open the possibility of additional new therapeutic approaches in this special type of mammary cancer in humans and dogs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7