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Comparative effects of bevacizumab, ranibizumab and pegaptanib at intravitreal dose range on endothelial cells

Title
Comparative effects of bevacizumab, ranibizumab and pegaptanib at intravitreal dose range on endothelial cells
Type
Article in International Scientific Journal
Year
2009
Authors
Ângela Carneiro
(Author)
FMUP
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Manuel Falcão
(Author)
Other
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Ana Pirraco
(Author)
Other
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Paula Milheiro Oliveira
(Author)
FEUP
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Fernando Falcão Reis
(Author)
FMUP
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Raquel Soares
(Author)
FMUP
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Journal
Vol. 88 No. 3
Pages: 522-527
ISSN: 0014-4835
Publisher: Elsevier
Indexing
Scientific classification
FOS: Medical and Health sciences > Clinical medicine
CORDIS: Physical sciences > Mathematics > Statistics ; Natural sciences > Biological sciences > Biological engineering
FOS: Medical and Health sciences > Medical biotechnology
Other information
Authenticus ID: P-003-MS6
Abstract (EN): Anti-VEGF therapy proved to be useful against several ocular pathological situations, including choroidal neovascularization and proliferative retinopathies. Ranibizumab (Ran), Pegaptanib (Peg) and Bev-acizumab (Bev) are the pharmacological agents more frequently used in clinical practice by intravitreal injection. However, their exact effects on the angiogenic process have not been accurately established in a comparative study. The aim of the present study was to elucidate the precise effects of Ran, Peg and Bev on the multiple steps of the angiogenic process. Human umbilical vein endothelial cells (HUVEC) were incubated with each agent within the clinically established concentration range, or identical amounts of the excipients; cell cytotoxicity, proliferation, apoptosis, migration and vessel assembly were assessed. No cytotoxic effects were found for any of the agents studied at any concentration tested. At the clinical dose, cell proliferation was significantly reduced by Bev and Ran, whereas no difference was observed after Peg treatment. In addition, HUVEC apoptosis was effectively increased by Bev and Ran. Cell migration was reduced after incubation with every agent analyzed, though only reaching statistical significance upon Ran intravitreal dose. At clinical doses, capillary assembly was only affected by Bev. In agreement with these data, the active form of VEGF receptor-2 expression was decreased after incubation with Bev (to 66% of control values), Ran (78%) and Peg (86%) relative to controls. These findings indicate that these three agents display distinct effects on endothelial cells.
Language: English
Type (Professor's evaluation): Scientific
Contact: angelacarneiro@netcabo.pt; falcao@med.up.pt; apirraco@gmail.com; poliv@fe.up.pt; falcao@med.up.pt; angelacarneiro@netcabo.pt
No. of pages: 6
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