Chromatographic pattern classification

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Antonio V Sousa (Author) Other; Ana Maria Mendonca (Author) FEUP; Aurelio Campilho (Author) FEUP

Journal

Title: IEEE Transactions on Biomedical Engineering

Vol. 55 No. 6

Pages: 1687-1696

ISSN: 0018-9294

Publisher: IEEE

Indexing

ISI Web of Knowledge - 7 Citations

ISI Web of Science

Scopus - 8 Citations

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

CORDIS: Technological sciences > Technology > Computer technology > Image processing

Other information

Authenticus ID: P-003-YV5

DOI: 10.1109/tbme.2008.919852

Abstract (EN): In this paper, we propose and evaluate methodologies for the classification of images from thin-layer chromatography. Each individual sample is characterized by an intensity profile that is further represented into a feature space. The first steps of this process aim at obtaining a robust estimate of the intensity profile by filtering noise, reducing the influence of background changes, and by fitting a mixture of Gaussians. The resulting profiles are represented by a set of appropriate features trying to characterize the state of nature, here spread out over four classes, one for normal subjects and the other three corresponding to lysosomal diseases, which are disorders responsible for severe nerve degeneration. For classification purposes, a novel solution based on a hierarchical structure is proposed. The main conclusion of this paper is that an automatically generated decision tree presents better results than more conventional solutions, being able to deal with the natural imbalance of the data that, as consequence of the rarity of lysosomal disorders, has very few representative cases in the disease classes when compared with the normal population.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10