Development of a system to adsorb drugs onto calcium phosphate materials

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Queiroz, AC (Author) Other; Santos, JD (Author) FEUP; Monteiro, FJ (Author) FEUP

Journal

Title: Journal of Materials Science: Materials in Medicine

Vol. 16

Pages: 641-646

ISSN: 0957-4530

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 14 Citations

ISI Web of Science

Scopus - 15 Citations

COMPENDEX

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

CORDIS: Technological sciences > Engineering > Biomaterial engineering

Other information

Authenticus ID: P-000-2MV

DOI: 10.1007/s10856-005-2535-3

Abstract (EN): Several studies were carried out in order to reduce the systemic use of antibiotics due to the high concentration required to provide the minimum inhibitory concentration (MIC) at infected sites. The aim of this study was to develop a system of drug adsorption onto commercial hydroxyapatite (HA, Ca-10(PO4)(6)(OH)(2)) and glass reinforced hydroxyapatite (GR-HA) granules. The drug will then be released for the local treatment of periodontitis. The antibiotics used in this study were metronidazole, a specific antibiotic indicated for the systemic treatment of periodontitis, and ampicillin, a wide spectrum antibiotic. UV spectroscopy was used to measure the amount of drug adsorbed onto HA and GR-HA granules. Results showed that metronidazole was unable to adsorb on the material's surface, as opposed to ampicillin which adsorbed both onto HA and GR-HA. Preliminary release kinetics studies were carried out using a flow through dissolution system. Results are discussed in terms of the influence of the different surface characteristics of the materials on the adsorption processes. (C) 2005 Springer Science + Business Media, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6