Role of Peroral Cholangioscopy for Diagnosis and Staging of Biliary Tumors

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Pereira, P (Author) Other; Santos, S (Author) Other; Morais, R (Author) Other; Gaspar, R (Author) Other; Rodrigues Pinto, E (Author) FMUP; Vilas Boas, F (Author) Other; Macedo G (Author) FMUP

Journal

Title: Digestive Diseases

Vol. 38

Pages: 431-439

ISSN: 0257-2753

Publisher: Karger

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-00R-NY1

DOI: 10.1159/000504910

Abstract (EN): Objectives:Peroral cholangioscopy (POC) has shown to be a useful diagnostic procedure in the evaluation of biliary strictures; however, data regarding its role on preoperative staging are scarce. The aim of this study was to evaluate POC role in the diagnosis and preoperative intraductal staging of perihilar cholangiocarcinoma (CCA).Methods:Retrospective study that included all patients who underwent POC withSpyGlass(TM)Direct Visualization Systemfor the diagnosis of biliary strictures or for preoperative evaluation of extrahepatic biliary tumors, between 2015 and 2019, in a single tertiary center.Results:Forty-three patients were included, 63% male with a median age of 62 years. Thirty-eight (88.3%) underwent POC due to indeterminate biliary strictures, 3 (7%) due to bile duct filling defect, and 2 (4.7%) for intraductal staging of perihilar CCA. In the follow-up, a final diagnosis of malignancy was established in 56% of the patients. Visual impression accuracy with SpyGlass was 95.1% (with 100% sensitivity and 89.5% specificity). SpyBite biopsies accuracy was 80.5% (63.6% sensitivity and 100% specificity). In the 19 patients with a final perihilar CCA diagnosis, intraductal evaluation with SpyGlass altered anatomic classification (Bismuth-Corlette) defined by previous imagiologic findings in 8 (42.1%) patients. Alteration in anatomic classification changed therapeutic approach in 4 (21%).Conclusions:POC use for evaluating intraductal spread in potentially resectable perihilar CCA can detect more extensive and change surgical management. In the future, preoperative staging of perihilar CCA with POC combined with imagiologic evaluation of vascular extension of the lesions may optimize surgical results.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9