A Second Life for MAP, a Model Amphipathic Peptide

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Silva, S (Author) Other; Kurrikoff, K (Author) Other; Langel, U (Author) Other; Almeida, AJ (Author) Other; Nuno Vale (Author) FMUP

Journal

Title: International Journal Of Molecular Sciences

Vol. 23

Final page: 8322

ISSN: 1661-6596

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-00W-Y37

DOI: 10.3390/ijms23158322

Abstract (EN): Cell-penetrating peptides (CPP) have been shown to be efficient in the transport of cargoes into the cells, namely siRNA and DNA, proteins and peptides, and in some cases, small therapeutics. These peptides have emerged as a solution to increase drug concentrations in different tissues and various cell types, therefore having a relevant therapeutic relevance which led to clinical trials. One of them, MAP, is a model amphipathic peptide with an alpha-helical conformation and both hydrophilic and hydrophobic residues in opposite sides of the helix. It is composed of a mixture of alanines, leucines, and lysines (KLALKLALKALKAALKLA). The CPP MAP has the ability to translocate oligonucleotides, peptides and small proteins. However, taking advantage of its unique properties, in recent years innovative concepts were developed, such as in silico studies of modelling with receptors, coupling and repurposing drugs in the central nervous system and oncology, or involving the construction of dual-drug delivery systems using nanoparticles. In addition to designs of MAP-linked vehicles and strategies to achieve highly effective yet less toxic chemotherapy, this review will be focused on unique molecular structure and how it determines its cellular activity, and also intends to address the most recent and frankly motivating issues for the future.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13