Desensitization of bladder sensory fibers by intravesical capsaicin of capsaicin analogs, a new strategy for treatment of urge incontinence in patients with spinal detrusor hyperreflexia or bladder hypersensitivity disorders

• Type: Another Publication in an International Scientific Journal
• Date: 1998

Authors

Francisco Cruz (Author) FMUP

Journal

Title: International Urogynecology Journal

Vol. 9

Pages: 214-220

ISSN: 0937-3462

Indexing

Scopus - 35 Citations

Other information

Authenticus ID: P-007-7W2

DOI: 10.1007/bf01901607

Abstract (EN): Recent experimental studies have identified a category of unmyelinated type C bladder afferent fibers in the pelvic nerves which are extremely sensitive to capsaicin. Sensory input conveyed by these fibers triggers a spinal reflex which, in chronic spinalized animals, facilitates and controls micturition. In addition, bladder C fibers were also shown to have a role in bladder pain perception. In humans capsaicin-sensitive afferent fibers also innervate the bladder and contribute to the reflexogenic control of the detrusor muscle and to bladder pain perception. Desensitization of such fibers by intravesical administration of capsaicin, presumably by blocking sensory transmission, has been shown to reduce involuntary micturition and to increase bladder capacity in patients with detrusor hyperreflexia of spinal origin, and to reduce the intensity of bladder pain in patients with bladder hypersensitivity. Very recently, resiniferatoxin, an ultrapotent capsaicin analog, was shown to have a similar clinical effect in this subset of patients. However, unlike capsaicin, resiniferatoxin did not evoke acute irritative urinary symptoms during bladder instillation.

Language: English

Type (Professor's evaluation): Scientific