Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Zoccali, G (Author) Other; Villasco, A (Author) Other; Biglia, N (Author) Other; Madalina, C (Author) Other; Costa, E (Author) Other; Daelemans, C (Author) Other; Pintiaux, A (Author) Other; Eyi, EGY (Author) Other; Cueto, E (Author) Other; Hadar, E (Author) Other; Dollinger, S (Author) Other; Brzezinski¿Sinai, NA (Author) Other; Huertas, E (Author) Other; Arango, P (Author) Other; Sanchez, A (Author) Other; Schvartzman, JA (Author) Other; Cojocaru, L (Author) Other; Turan, S (Author) Other; Turan, O (Author) Other; Di Dedda, MC (Author) Other; Molpeceres, RG (Author) Other; Zdjelar, S (Author) Other; Premru¿Srsen, T (Author) Other; Kornhauser¿Cerar, L (Author) Other; Dru¨kovi¿, M (Author) Other; De Robertis, V (Author) Other; Stefanovic, V (Author) Other; Nupponen, I (Author) Other; Nelskylä, K (Author) Other; Khodjaeva, Z (Author) Other; Gorina, KA (Author) Other; Sukhikh, GT (Author) Other; Maruotti, GM (Author) Other; Visentin, S (Author) Other; Cosmi, E (Author) Other; Ferrari, J (Author) Other; Gatti, A (Author) Other; Luvero, D (Author) Other; Angioli, R (Author) Other; Puri, L (Author) Other; Palumbo, M (Author) Other; D'Urso, G (Author) Other; Colaleo, F (Author) Other; Rapisarda, AMC (Author) Other; Carbone, IF (Author) Other; Manzoli, L (Author) Other; Flacco, ME (Author) Other; Nazzaro, G (Author) Other; Locci, M (Author) Other; Guida, M (Author) Other; Sardo, ADS (Author) Other; Panici, PB (Author) Other; Khalil, A (Author) Other; Berghella, V (Author) Other; Bifulco, G (Author) Other; Scambia, G (Author) Other; Zullo, F (Author) Other; D'Antonio, F (Author) Other; Saccone, G (Author) Other; Sen, C (Author) Other; Di Mascio, D (Author) Other; Galindo, A (Author) Other; Grünebaum, A (Author) Other; Yoshimatsu, J (Author) Other; Stanojevic, M (Author) Other; Kurjak, A (Author) Other; Chervenak, F (Author) Other; Suárez, MJR (Author) Other; Gambacorti¿Passerini, ZM (Author) Other; de los Angeles Anaya Baz, M (Author) Other; Galán, EVA (Author) Other; López, YC (Author) Other; Luis, JADL (Author) Other; Hernández, IC (Author) Other; Herraiz, I (Author) Other; Villalain, C (Author) Other; Venturella, R (Author) Other; Rizzo, G (Author) Other; Mappa, I (Author) Other; Gerosolima, G (Author) Other; Hellmeyer, L (Author) Other; Königbauer, J (Author) Other; Ameli, G (Author) Other; Frusca, T (Author) Other; Volpe, N (Author) Other; Schera, GBL (Author) Other; Fieni, S (Author) Other; Esposito, E (Author) Other; Simonazzi, G (Author) Other; Di Donna, G (Author) Other; Youssef, A (Author) Other; Gatta, AND (Author) Other; Di Donna, MC (Author) Other; Chiantera, V (Author) Other; Buono, N (Author) Other; Sozzi, G (Author) Other; Greco, P (Author) Other; Morano, D (Author) Other; Bianchi, B (Author) Other; Marino, MGL (Author) Other; Laraud, F (Author) Other; Ramone, A (Author) Other; Cagnacci, A (Author) Other; Barra, F (Author) Other; Gustavino, C (Author) Other; Ferrero, S (Author) Other; Ghezzi, F (Author) Other; Cromi, A (Author) Other; Laganà, AS (Author) Other; Longo, VL (Author) Other; Stollagli, F (Author) Other; Sirico, A (Author) Other; Lanzone, A (Author) Other; Driul, L (Author) Other; Cecchini, F (Author) Other; Xodo, S (Author) Other; Rodriguez, B (Author) Other; Mercado¿Olivares, F (Author) Other; Elkafrawi, D (Author) Other; Sisti, G (Author) Other; Esposito, R (Author) Other; Coviello, A (Author) Other; Cerbone, M (Author) Other; Morlando, M (Author) Other; Schiattarella, A (Author) Other; Colacurci, N (Author) Other; De Franciscis, P (Author) Other; Cataneo, I (Author) Other; Lenzi, M (Author) Other; Sandri, F (Author) Other; Buscemi, R (Author) Other; Gattei, G (Author) Other; Sala, FD (Author) Other; Valori, E (Author) Other; Rovellotti, MC (Author) Other; Done, E (Author) Other; Faron, G (Author) Other; Gucciardo, L (Author) Other; Esposito, V (Author) Other; Vena, F (Author) Other; Giancotti, A (Author) Other; Brunelli, R (Author) Other; Muzii, L (Author) Other; Nappi, L (Author) Other; Sorrentino, F (Author) Other; Liberati, M (Author) Other; Buca, D (Author) Other; Leombroni, M (Author) Other; Di Sebastiano, F (Author) Other; Franchi, M (Author) Other; Ianniciello, QC (Author) Other; Garzon, S (Author) Other; Petriglia, G (Author) Other; Borrello, L (Author) Other; Nieto¿Calvache, AJ (Author) Other; Burgos¿Luna, JM (Author) Other; Kadji, C (Author) Other; Carlin, A (Author) Other; Bevilacqua, E (Author) Other; Moucho, M (Author) Other; Viana Pinto, P (Author) FMUP; Figueiredo, R (Author) Other; Morales Roselló, J (Author) Other; Loscalzo, G (Author) Other; Martinez¿Varea, A (Author) Other; Diago, V (Author) Other; Jimenez Lopez, JS (Author) Other; Aykanat, AY (Author) Other; Cosma, S (Author) Other; Carosso, A (Author) Other; Benedetto, C (Author) Other; Bermejo, A (Author) Other; Feuerschuette, OHM (Author) Other; Uyaniklar, O (Author) Other; Ocakouglu, SR (Author) Other; Atak, Z (Author) Other; Gündüz, R (Author) Other; Haberal, ET (Author) Other; Froessler, B (Author) Other; Parange, A (Author) Other; Palm, P (Author) Other; Samardjiski, I (Author) Other; Taccaliti, C (Author) Other; Okuyan, E (Author) Other; Daskalakis, G (Author) Other; de Sa, RAM (Author) Other; Pittaro, A (Author) Other; Gonzalez¿Duran, ML (Author) Other; Guisan, AC (Author) Other; Genç, ¿Ö (Author) Other; Zlatohlávková, B (Author) Other; Piqueras, AL (Author) Other; Oliva, DE (Author) Other; Cil, AP (Author) Other; Api, O (Author) Other; Antsaklis, P (Author) Other; Ples, L (Author) Other; Kyvernitakis, I (Author) Other; Maul, H (Author) Other; Malan, M (Author) Other; Lila, A (Author) Other; Granese, R (Author) Other; Ercoli, A (Author) Other

Journal

Title: Ultrasound in Obstetrics and Gynecology

Vol. 57

Pages: 232-241

ISSN: 0960-7692

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 58 Citations

Scopus - 86 Citations

Other information

Authenticus ID: P-00V-WYH

DOI: 10.1002/uog.23107

Abstract (EN): Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251(27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. (C) 2020 International Society of Ultrasound in Obstetrics and Gynecology.

Language: English

Type (Professor's evaluation): Dissemination

No. of pages: 10