Cytotoxic Effect of Silver Nanoparticles Synthesized by Green Methods in Cancer

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Morais, M (Author) Other; Teixeira, AL (Author) Other; Dias, F (Author) Other; Machado, V (Author) Other; Rui Medeiros (Author) ICBAS; Joao A V Prior (Author) FFUP

Journal

Title: Journal of Medicinal Chemistry

Vol. 63

ISSN: 0022-2623

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 62 Citations

Scopus - 66 Citations

Other information

Authenticus ID: P-00T-7SZ

DOI: 10.1021/acs.jmedchem.0c01055

Abstract (EN): Cancer is a major public health problem, but despite the several treatment approaches available, patients develop resistance in short time periods, making overcoming resistance or finding more efficient treatments an imperative challenge. Silver nanoparticles (AgNPs) have been described as an alternative option due to their physicochemical properties. The scope of this review was to systematize the available scientific information concerning these characteristics in AgNPs synthesized according to green chemistry's recommendations as well as their cytotoxicity in different cancer models. This is the first paper analyzing, correlating, and summarizing AgNPs' main parameters that modulate their cellular effect, including size, shape, capping, and surface plasmon resonance profile, dose range, and exposure time. It highlights the strong dependence of AgNPs' cytotoxic effects on their characteristics and tumor model, making evident the strong need of standardization and full characterization. AgNPs' application in oncology research is a new, open, and promising field and needs additional studies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 28