Association between ambulatory blood pressure values and central aortic pressure in a large population of normotensive and hypertensive patients

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Rouxinol Dias, A (Author) FMUP; Araujo, S (Author) Other; Silva, JA (Author) Other; Barbosa, L (Author) Other; Polonia, J (Author) FMUP

Journal

Title: Blood Pressure Monitoring

Vol. 23

Pages: 24-32

ISSN: 1359-5237

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00N-Q05

DOI: 10.1097/mbp.0000000000000287

Abstract (EN): Objective Our aim was to examine the association of ambulatory blood pressure monitoring (ABPM) and central blood pressure (CBP) data in a large set of normotensive and hypertensive patients and its relation with pulse wave velocity (PWV). Patients and methods This cross-sectional study was carried out in a single centre and included 2864 individuals who carried out an ABPM, measurement of CBP from the aortic waveform (SphygmoCor) and carotid-femoral PWV (Complior). Results In our study, 26.6% of the normotensive individuals and 32.5% of controlled hypertensive patients had abnormal values of at least one or of both ABPM and CBP values, compared with 96.6% of uncontrolled hypertensive patients. In the overall population, normal ABPM and CBP occurred in 25.3% (group 1), abnormal ABPM and CBP occurred in 44.4% (group 4), abnormal ABPM and normal CBP occurred in 10.5% (group 3) and normal ABPM and abnormal CBP occurred in 19.8% (group 2). PWV was significantly superior in group 4 versus group 3; group 4 versus group 1 and group 3 versus group 2 and group 2 versus group 1 (Mann-Whitney U-test; P<0.001). Conclusion At least 26-32% of patients classified as normotensive or controlled hypertensive patients have abnormal ABPM or CBP associated with target organ damages. When abnormal values of ABPM and CBP coexist, target organ damage (aortic stiffness) is greater than that occurring when only one abnormal ABPM or CBP is present in the absence of the other. Isolated central hypertension entails greater organ damage than both normal ABPM and CBP. These patients may be at higher risk of further target organ damage because of unawareness of their central hypertension. Copyright

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9