Assessment of Bonelike (R) graft with a resorbable matrix using an animal model

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Lobato, JV (Author) Other; Sooraj S Hussain (Author) Other; Botelho, CM (Author) Other; Mauricio, AC (Author) ICBAS; Américo Afonso (Author) FMDUP; Ali, N (Author) Other; Santos, JD (Author) FEUP

Journal

Title: Thin Solid Films

Vol. 515

Pages: 362-367

ISSN: 0040-6090

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 14 Citations

INSPEC

COMPENDEX

Scientific classification

FOS: Engineering and technology > Materials engineering

CORDIS: Technological sciences > Technology > Medical technology > Biomedical materials ; Technological sciences > Engineering > Biomedical enginnering

Other information

Authenticus ID: P-004-H5H

DOI: 10.1016/j.tsf.2005.12.153

Abstract (EN): Synthetic bone grafts have been developed to provide an alternative to autografts and allografts. Bonelike((R)) is a patented synthetic osteoconductive bone graft that mimics the mineral composition of natural bone, In the present preliminary animal studies a user-firiendly version of synthetic bone graft Bonelike((R)) have been developed by using a resorbable matrix, Floseal((R)), as a vehicle and raloxifene hydrochloride as a therapeutic molecule, that is known to decrease osteoclast activity and therefore enhanced bone formation. From histological and scanning electron microscopy evaluations, the use of Bonelike((R)) associated with Floseal((R)) and raloxifene hydrochloride showed that new bone was rapidly apposed on implanted granules and also that the presence of the matrix and therapeutic molecule does not alter the proven highly osteoconductivity properties of Bonelike((R)). Therefore, this association may be one step-forward for the clinical applications of Bonelike((R)) scaffolds since it is much more easy-to-handle when compared to granular materials.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6