Transient Disabling Dyskinesias: A Predictor of Good Outcome in Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Gago, MF (Author) Other; Rosas, MJ (Author) Other; Linhares, P (Author) FMUP; Ayres Basto, M (Author) Other; Sousa, G (Author) Other; Vaz, R (Author) Other

Journal

Title: European Neurology

Vol. 61

Pages: 94-99

ISSN: 0014-3022

Publisher: Karger

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-003-PXW

DOI: 10.1159/000177941

Abstract (EN): We report 5 of 75 (6.6%) patients with Parkinson's disease (PD) submitted to subthalamic nucleus deep brain stimulation (STN-DBS) who developed transient disabling dyskinesias immediately after surgery. Dyskinesias persisted despite levodopa withdrawal, cessation or reduction of stimulation, and resolved spontaneously in a maximum period of 12 weeks without the need to change stimulation active contact. Compared to the rest of our PD patients submitted to STN-DBS, the dyskinesia group needed a lower levodopa-equivalent daily dosage (LEDD) over the time of follow-up. A microlesion in the STN, probably concealed in cerebral MRI by the electrode-related artifact, could have been involved in the etiopathology of our patients' symptoms. The presence of transient disabling dyskinesia in PD patients immediately after STN-DBS might be a predictor of good outcome as measured by a decrease in the LEDD needed. Copyright (C) 2008 S. Karger AG, Basel

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6