Early pseudoprogression following chemoradiotherapy in glioblastoma patients: The value of RANO evaluation

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Linhares, P (Author) FMUP; Carvalho, B (Author) FMUP; Figueiredo, R (Author) Other; Reis, RM (Author) Other; Vaz, R (Author) Other

Journal

Title: Journal of Oncology

Vol. 2013

Pages: 1-9

ISSN: 1687-8450

Publisher: Hindawi

Indexing

Scopus - 43 Citations

Other information

Authenticus ID: P-008-E4Q

DOI: 10.1155/2013/690585

Abstract (EN): Introduction. The aim of this study was to determine the frequency of pseudoprogression in a cohort of glioblastoma (GBM) patients following radiotherapy/temozolomide (RT/TMZ) by comparing Macdonald criterial to Response Assessment in Neuro-Oncology (RANO) criteria. The impact on prognosis and survival analysis was also studied. Materials and Methods. All patients receiving RT/TMZ for newly diagnosed GBM from January 2005 to December 2009 were retrospectively evaluated, and demographic, clinical, radiographic, treatment, and survival data were reviewed. Updated RANO criteria were used for the evaluation of the pre-RT and post-RT MRI and compared to classic Macdonald criteria. Survival data was evaluated using the Kaplan-Meier and log-rank analysis. Results and Discussion. 70 patients were available for full radiological response assessment. Early progression was confirmed in 42 patients (60%) according to Macdonald criteria and 15 patients (21%) according to RANO criteria. Pseudoprogression was identified in 10 (23.8%) or 2 (13.3%) patients in Macdonald and RANO groups, respectively. Cumulative survival of pseudoprogression group was higher than that of true progression group and not statistically different from the non-progressive disease group. Conclusion. In this cohort, the frequency of pseudoprogression varied between 13% and 24%, being overdiagnosed by older Macdonald criteria, which emphasizes the importance of RANO criteria and new radiological biomarkers for correct response evaluation. © 2013 Paulo Linhares et al.

Language: English

Type (Professor's evaluation): Scientific