Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Merino-Ribas, A (Author) Other; Araujo, R (Author) Other; Pereira, L (Author) Other; Campos, J (Author) Other; Barreiros, L (Author) Other; Marcela A Segundo (Author) FFUP; Silva, N (Author) Other; Costa, CFFA (Author) Other; Quelhas-Santos, J (Author) FMUP; Trindade, F (Author) Other; Falcao Pires, I (Author) FMUP; Alencastre, I (Author) Other; Dumitrescu, IB (Author) Other; Benedita Sampaio-Maia (Author) FMDUP

Journal

Title: Biomolecules

Vol. 12

Final page: 867

ISSN: 2218-273X

Publisher: MDPI

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 24 Citations

Other information

Authenticus ID: P-00W-SQ9

DOI: 10.3390/biom12070867

Abstract (EN): Vascular calcification (VC) is a frequent condition in chronic kidney disease (CKD) and a well-established risk factor for the development of cardiovascular disease (CVD). Gut dysbiosis may contribute to CVD and inflammation in CKD patients. Nonetheless, the role of gut and blood microbiomes in CKD-associated VC remains unknown. Therefore, this pilot study aimed to explore the link between gut and blood microbiomes and VC in CKD patients on peritoneal dialysis (CKD-PD). Our results showed relative changes in specific taxa between CKD-PD patients with and without VC, namely Coprobacter, Coprococcus 3, Lactobacillus, and Eubacterium eligens group in the gut, and Cutibacterium, Pajaroellobacter, Devosia, Hyphomicrobium, and Pelomonas in the blood. An association between VC and all-cause mortality risk in CKD-PD patients was also observed, and patients with higher mortality risk corroborate the changes of Eubacterium eligens in the gut and Devosia genus in the blood. Although we did not find differences in uremic toxins, intestinal translocation markers, and inflammatory parameters among CKD-PD patients with and without VC, soluble CD14 (sCD14), a nonspecific marker of monocyte activation, positively correlated with VC severity. Therefore, gut Eubacterium eligens group, blood Devosia, and circulating sCD14 should be further explored as biomarkers for VC, CVD, and mortality risk in CKD.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16