The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Mosteo, L (Author) Other; Storer, J (Author) Other; Batta, K (Author) Other; Searle, EJ (Author) Other; Duarte, D (Author) FMUP; Wiseman, DH (Author) Other

Journal

Title: Frontiers in Cell and Developmental Biology

Vol. 9

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-00T-P8H

DOI: 10.3389/fcell.2021.635189

Abstract (EN): Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment performed in mouse studies. We also discuss the emerging role of the vascular niche in "inflamm-aging" and clonal hematopoiesis, and how the endothelial microenvironment influences, supports and interacts with hematopoietic cells in acute myeloid leukemia and myelodysplastic syndromes, as exemplar states of malignant myelopoiesis. Finally, we provide an overview of strategies for modulating these bidirectional interactions to therapeutic effect in myeloid malignancies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 24