The Role of Iron in Benign and Malignant Hematopoiesis

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Sinha, S (Author) Other; Pereira Reis, J (Author) Other; Guerra, A (Author) Other; Rivella, S (Author) Other; Duarte, D (Author) FMUP

Journal

Title: ANTIOXIDANTS & REDOX SIGNALING

Vol. 35

Pages: 415-432

ISSN: 1523-0864

Publisher: Mary Ann Liebert

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00T-915

DOI: 10.1089/ars.2020.8155

Abstract (EN): Significance: Iron is an essential element required for sustaining a normal healthy life. However, an excess amount of iron in the bloodstream and tissue generates toxic hydroxyl radicals through Fenton reactions. Henceforth, a balance in iron concentration is extremely important to maintain cellular homeostasis in both normal hematopoiesis and erythropoiesis. Iron deficiency or iron overload can impact hematopoiesis and is associated with many hematological diseases. Recent Advances: The mechanisms of action of key iron regulators such as erythroferrone and the discovery of new drugs, such as ACE-536/luspatercept, are of potential interest to treat hematological disorders, such as beta-thalassemia. New therapies targeting inflammation-induced ineffective erythropoiesis are also in progress. Furthermore, emerging evidences support differential interactions between iron and its cellular antioxidant responses of hematopoietic and neighboring stromal cells. Both iron and its systemic regulator, such as hepcidin, play a significant role in regulating erythropoiesis. Critical Issues: Significant pre-clinical studies are on the way and new drugs targeting iron metabolism have been recently approved or are undergoing clinical trials to treat pathological conditions with impaired erythropoiesis such as myelodysplastic syndromes or beta-thalassemia. Future Directions: Future studies should explore how iron regulates hematopoiesis in both benign and malignant conditions. Antioxid. Redox Signal. 35, 415-432.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18