Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Domingues, HS (Author) Other; Portugal, CC (Author) Other; Socodato, R (Author) Other; Relvas, JB (Author) ICBAS

Journal

Title: Frontiers in Cell and Developmental Biology

Vol. 23

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 103 Citations

Other information

Authenticus ID: P-00T-46D

DOI: 10.3389/fcell.2016.00071

Abstract (EN): Oligodendrocytes are the myelinating glia of the central nervous system. Myelination of axons allows rapid saltatory conduction of nerve impulses and contributes to axonal integrity. Devastating neurological deficits caused by demyelinating diseases, such as multiple sclerosis, illustrate well the importance of the process. In this review, we focus on the positive and negative interactions between oligodendrocytes, astrocytes, and microglia during developmental myelination and remyelination. Even though many lines of evidence support a crucial role for glia crosstalk during these processes, the nature of such interactions is often neglected when designing therapeutics for repair of demyelinated lesions. Understanding the cellular and molecular mechanisms underlying glial cell communication and how they influence oligodendrocyte differentiation and myelination is fundamental to uncover novel therapeutic strategies for myelin repair.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16