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dMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation

Title
dMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation
Type
Article in International Scientific Journal
Year
2017
Authors
Tavares, L
(Author)
Other
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Correia, A
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Santos, MA
(Author)
Other
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Relvas, JB
(Author)
ICBAS
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Pereira, PS
(Author)
Other
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Journal
Title: Plos GeneticsImported from Authenticus Search for Journal Publications
Vol. 13
ISSN: 1553-7390
Other information
Authenticus ID: P-00M-MZQ
Abstract (EN): In the nervous system, glial cells provide crucial insulation and trophic support to neurons and are important for neuronal survival. In reaction to a wide variety of insults, glial cells respond with changes in cell morphology and metabolism to allow repair. Additionally, these cells can acquire migratory and proliferative potential. In particular, after axonal damage or pruning the clearance of axonal debris by glial cells is key for a healthy nervous system. Thus, bidirectional neuron-glial interactions are crucial in development, but little is known about the cellular sensors and signalling pathways involved. In here, we show that decreased cellular fitness in retinal progenitors caused by reduced Drosophila Myc expression triggers non cellautonomous activation of retinal glia proliferation and overmigration. Glia migration occurs beyond its normal limit near the boundary between differentiated photoreceptors and precursor cells, extending into the progenitor domain. This overmigration is stimulated by JNK activation (and the function of its target Mmp1), while proliferative responses are mediated by Dpp/TGF-beta signalling activation.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 24
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