Mechanical plasticity during oligodendrocyte differentiation and myelination

• Type: Another Publication in an International Scientific Journal
• Date: 2018

Authors

Domingues, HS (Author) Other; Cruz, A (Author) Other; Chan, JR (Author) Other; Relvas, JB (Author) ICBAS; Rubinstein, B (Author) Other; Pinto, IM (Author) Other

Journal

Title: GLIA

Vol. 66

Pages: 5-14

ISSN: 0894-1491

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 24 Citations

Other information

Authenticus ID: P-00N-8BH

DOI: 10.1002/glia.23206

Abstract (EN): In the central nervous system, oligodendrocyte precursor cells are exclusive in their potential to differentiate into myelinating oligodendrocytes. Oligodendrocyte precursor cells migrate within the parenchyma and extend cell membrane protrusions that ultimately evolve into myelinating sheaths able to wrap neuronal axons and significantly increase their electrical conductivity. The subcellular force generating mechanisms driving morphological and functional transformations during oligodendrocyte differentiation and myelination remain elusive. In this review, we highlight the mechanical processes governing oligodendrocyte plasticity in a dynamic interaction with the extracellular matrix.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10