Platinum-drugs Ototoxicity in Pediatric Patients With Brain Tumors: A 10-Year Review

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Rabico Costa, D (Author) Other; Gil da Costa, MJ (Author) Other; Barbosa, JP (Author) FMUP; Bom Sucesso, M (Author) Other; Jorge Spratley (Author) FMUP

Journal

Title: Journal of Pediatric Hematology/Oncology

Vol. 42

Pages: E25-E31

ISSN: 1077-4114

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00R-GGY

DOI: 10.1097/mph.0000000000001637

Abstract (EN): Purpose: Platinum-derived chemotherapy is one of the cornerstones in the treatment of central nervous system tumors in children. We aimed to assess the incidence of hearing loss in children after the exposure to platinum drugs. Material and Methods: Retrospective study of prospectively collected data on children consecutively diagnosed with brain tumors and treated with platinum derivatives at a tertiary referral hospital between January 2006 and December 2015. We analyzed multiples variables, such as: age at diagnosis, tumor location, hydrocephalus, platinum drug type, radiotherapy, and follow-up time. The final sample size was 51 patients. Results: The median age at diagnosis was 6 years. The median overall follow-up time was 75 months. The incidence of ototoxicity was 23.5%. Rates of hearing loss with carboplatinum were lower than with cisplatinum. A statistically significant association occurred between the presence of hydrocephalus, radiotherapy exposure, infratentorial tumor location, and ototoxicity after treatment with platinum derivatives. Conclusions: Childhood central nervous system tumors nowadays exhibit improved cure and survival rates. However, the ototoxicity resulting from the chemotherapy treatment may accompany patients for the rest of their lives. This study reveals that this occurrence is not negligible, and the association of radiotherapy and the presence of hydrocephalus can be potentiating factors.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7