Histological variability and the importance of clinicopathological correlation in cutaneous Rosai-Dorfman disease

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Gameiro, A (Author) Other; Gouveia, M (Author) Other; Cardoso, JC (Author) Other; Tellechea, O (Author) Other

Journal

Title: Anais Brasileiros de Dermatologia

Vol. 91

Pages: 634-637

ISSN: 0365-0596

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-00M-6SW

DOI: 10.1590/abd1806-4841.20164477

Abstract (EN): Rosai-Dorfman disease is a benign histiocytic proliferative disorder of unknown etiology. The disease mainly affects lymph node tissue, although it is rarely confined to the skin. Here, we describe a 53-year-old woman with purely cutaneous Rosai-Dorfman disease. The patient presented with a large pigmented plaque on her left leg, and sparse erythematous papules on her face and arms. A complete clinical response was achieved with thalidomide, followed by recurrence at the initial site one year later. The histological examination displayed the typical features of Rosai-Dorfman disease in the recent lesions but not in the older lesions. In the setting of no lymphadenopathy, the histopathological features of Rosai-Dorfman disease are commonly misinterpreted. Therefore, awareness of the histological aspects present at different stages, not always featuring the hallmark microscopic signs of Rosai-Dorfman disease, is particularly important for a correct diagnosis of this rare disorder.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4