Rheological characterization of polymeric solutions used in spray drying process

• Type: Article in International Scientific Journal
• Date: 2021-03-01

Authors

Campo Deano, L (Author) FEUP; Galindo Rosales, FJ (Author) FEUP; Tiago Porfírio (Author) Other; João Vicente (Author) Other; Viriato Semião (Author) Other

Journal

Title: European Journal of Pharmaceutical Sciences

Vol. 158

ISSN: 0928-0987

Publisher: Elsevier

Indexing

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Other information

Authenticus ID: P-00T-66B

DOI: 10.1016/j.ejps.2020.105650

Abstract (EN): The present works contributes with a rheological characterization of the most commonly used polymers and solvents to formulate amorphous solid dispersions by means of spray drying process: copovidone, hydroxypropyl methylcellulose (HPMC), hydroxypropyl methylcellulose acetate succinate (HPMCAS) and a copolymer of methacrylic acid and methyl methacrylate (1:1 ratio and commercially known as Eudragit L100). The organic-based solutions are characterized in terms of surface tension, shear viscosity and relaxation time. HPMC and HPMCAS solutions exhibit shear thinning behaviour, i.e. decrease of shear viscosity with the increasing shear rate imposed, while the samples with Eudragit L100 can be considered Boger fluids, showing a constant viscosity but maintaining its viscoelastic character. Under uniaxial extensional flow, these polymers solutions exhibit a viscoelastic behavior with an increasing relaxation time with an increasing concentration, and in some cases showed a 'beads-on-string' effect. In contrast, copovidone showed a Newtonian fluid behavior, with the absence of elasticity. The fundamental understanding and characterization of the present work may be further applied to atomization modelling and support and expedite spray drying process development.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10