Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Silva, AT (Author) Other; Oliveira, IS (Author) Other; Gomes, J (Author) Other; Aguiar, L (Author) Other; Fontinha, D (Author) Other; Duarte, D (Author) Other; Nogueira, F (Author) Other; Prudencio, M (Author) Other; Eduardo F Marques (Author) FCUP; Catia Teixeira (Author) FCUP; Ferraz, R (Author) Other; Paula Gomes (Author) FCUP

Journal

Title: ChemMedChem

Vol. 17

ISSN: 1860-7179

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-00V-T2M

DOI: 10.1002/cmdc.202100650

Abstract (EN): Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5