Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Zacchigna, S (Author) Other; Paldino, A (Author) Other; Falcao Pires, I (Author) Other; Daskalopoulos, EP (Author) Other; Dal Ferro, M (Author) Other; Vodret, S (Author) Other; Lesizza, P (Author) Other; Cannata, A (Author) Other; Miranda Silva, D (Author) FMUP; Andre P Lourenco (Author) FMUP; Pinamonti, B (Author) Other; Sinagra, G (Author) Other; Weinberger, F (Author) Other; Eschenhagen, T (Author) Other; Carrier, L (Author) Other; Kehat, I (Author) Other; Tocchetti, CG (Author) Other; Russo, M (Author) Other; Ghigo, A (Author) Other; Cimino, J (Author) Other; Hirsch, E (Author) Other; Dawson, D (Author) Other; Ciccarelli, M (Author) Other; Oliveti, M (Author) Other; Linke, WA (Author) Other; Cuijpers, I (Author) Other; Heymans, S (Author) Other; Hamdani, N (Author) Other; de Boer, M (Author) Other; Duncker, DJ (Author) Other; Kuster, D (Author) Other; van der Velden, J (Author) Other; Beauloye, C (Author) Other; Bertrand, L (Author) Other; Mayr, M (Author) Other; Giacca, M (Author) Other; Leuschner, F (Author) Other; Backs, J (Author) Other; Thum, T (Author) Other

Journal

Title: Cardiovascular Research

Vol. 117

Pages: 43-59

ISSN: 0008-6363

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 66 Citations

Scopus - 70 Citations

Other information

Authenticus ID: P-00S-FDA

DOI: 10.1093/cvr/cvaa110

Abstract (EN): Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions. [GRAPHICS] .

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17