OCT-angiography detects longitudinal microvascular changes in glaucoma: a systematic review

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Miguel, A (Author) Other; Silva, A (Author) Other; Barbosa Breda, J (Author) FMUP; Azevedo L (Author) FMUP; Abdulrahman, A (Author) Other; Hereth, E (Author) Other; Pinto, LA (Author) Other; Lachkar, Y (Author) Other; Stalmans, I (Author) Other

Journal

Title: British Journal of Ophthalmology

ISSN: 0007-1161

Publisher: BMJ PUBLISHING GROUP

Indexing

ISI Web of Knowledge - 19 Citations

Scopus - 20 Citations

Other information

Authenticus ID: P-00T-9TV

DOI: 10.1136/bjophthalmol-2020-318166

Abstract (EN): Background/aims Optical coherence tomography angiography (OCTA) allows the study of vessel density (VD). We intended to perform a systematic review of studies focusing on longitudinal changes in peripapillary and macular VD measurements in glaucoma. Methods A search was performed across MEDLINE, Scopus, ISI Web of Science and Google Scholar, using the following query from inception until 20 September 2019: (("optical coherence tomography angiography"[tiab]) OR (optical coherence tomography angiography[MeSH]) OR ("OCTA"[tiab]) OR ("OCT-A"[tiab]) OR ("angio-OCT"[tiab]) OR ("OCT- angiography"[tiab]) OR ("OCT-angio"[tiab]) OR ("OCT-angiographie"[tiab])) AND (glaucom*[tiab] OR glaucoma[MeSH]). Prospective studies that quantitatively assessed the longitudinal changes in VD in glaucoma with at least 3 months of follow-up were included. Results Ten out of 4516 studies were included. The rate of VD change in glaucoma varied from 0.036/year to 1.08/year and 1.3% to 3.2% per year, with significantly different rates between glaucoma and healthy controls. Five studies assessed VD change after glaucoma surgery, obtaining variable results, ranging from a temporary VD decrease to increase after 3 months. Meta-analysis was not possible due to a wide variation in methods, measurements and region of VD. Conclusion OCTA is a non-invasive technology, which shows promise in glaucoma. Measures should be taken to increase the quality and standardise the methodology of VD measures in OCTA longitudinal studies, for future meta-analyses.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9