From bladder to systemic syndrome: concept and treatment evolution of interstitial cystitis

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Dinis, S (Author) Other; de Oliveira, JT (Author) Other; Pinto, R (Author) FMUP; Francisco Cruz (Author) FMUP; Buffington, CT (Author) Other; Paulo Dinis (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: INTERNATIONAL JOURNAL OF WOMENS HEALTH

Vol. 7

Pages: 735-744

ISSN: 1179-1411

Publisher: DOVE MEDICAL PRESS LTD

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-00G-E5M

DOI: 10.2147/ijwh.s60798

Abstract (EN): Interstitial cystitis, presently known as bladder pain syndrome, has been recognized for over a century but is still far from being understood. Its etiology is unknown and the syndrome probably harbors different diseases. Autoimmune dysfunction, urothelial leakage, infection, central and peripheral nervous system dysfunction, genetic disease, childhood trauma/abuse, and subsequent stress response system dysregulation might be implicated. Management is slowly evolving from a solo act by the end-organ specialist to a team approach based on new typing and phenotyping of the disease. However, oral and invasive treatments are still largely aimed at the bladder and are based on currently proposed pathophysiologic mechanisms. Future research will better define the disease, permitting individualization of treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10