Plk1 puts a (Has)pin on the mitotic histone code

• Type: Another Publication in an International Scientific Journal
• Date: 2014

Authors

Moutinho Santos, T (Author) Other; Helder Maiato (Author) FMUP

Journal

Title: EMBO Reports

Vol. 15

Pages: 203-204

ISSN: 1469-221X

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-009-81J

DOI: 10.1002/embr.201438472

Abstract (EN): Haspin is an atypical mitotic kinase that phosphorylates histone H3 on threonine 3 (H3T3), which is required to target Aurora B to centromeres. However, how Haspin is activated upon mitotic entry remained unknown. Two independent studies, published in Molecular Cell and in this issue of EMBO reports by Ghenoiu et al [1] and Zhou et al [2], respectively, now show that Plk1 is responsible for Haspin activation as a H3T3 kinase. These results shed light on the spatiotemporal regulation of Aurora B to ensure mitotic fidelity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 2