The Tubulin Code: A Navigation System for Chromosomes during Mitosis

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Barisic, M (Author) Other; Helder Maiato (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: TRENDS IN CELL BIOLOGY

Vol. 26

Pages: 766-775

ISSN: 0962-8924

Publisher: Elsevier Science

Indexing

ISI Web of Knowledge - 40 Citations

Scopus - 41 Citations

Other information

Authenticus ID: P-00M-4B3

DOI: 10.1016/j.tcb.2016.06.001

Abstract (EN): Before chromosomes segregate during mitosis in metazoans, they align at the cell equator by a process known as chromosome congression. This is in part mediated by the coordinated activities of kinetochore motors with opposite directional preferences that transport peripheral chromosomes along distinct spindle microtubule populations. Because spindle microtubules are all made from the same alpha/beta-tubulin heterodimers, a critical longstanding question has been how chromosomes are guided to specific locations during mitosis. This implies the existence of spatial cues/signals on specific spindle micro tubules that are read by kinetochore motors on chromosomes and ultimately indicate the way towards the equator. Here, we discuss the emerging concept that tubulin post-translational modifications (PTMs), as part of the so-called tubulin code, work as a navigation system for kinetochore-based chromosome motility during early mitosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10