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Stuck in division or passing through: What happens when cells cannot satisfy the spindle assembly checkpoint

Title
Stuck in division or passing through: What happens when cells cannot satisfy the spindle assembly checkpoint
Type
Another Publication in an International Scientific Journal
Year
2004
Authors
Rieder, CL
(Author)
Other
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Helder Maiato
(Author)
Other
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Journal
Title: Developmental CellImported from Authenticus Search for Journal Publications
Vol. 7
Pages: 637-651
ISSN: 1534-5807
Publisher: Elsevier
Other information
Authenticus ID: P-008-PSF
Abstract (EN): Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-mitosis), a fact that has useful clinical ramifications. However, this delay is seldom permanent, and in the presence of an active SAC most cells ultimately escape mitosis and enter the next G1 as tetraploid cells. This review defines and discusses the various factors that determine how long a cell remains in mitosis when it cannot satisfy the SAC and also discusses the cell's subsequent fate.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 15
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