Intraoperative microelectrode recording in Parkinson's disease subthalamic deep brain stimulation: Analysis of clinical utility

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Soares, MI (Author) Other; Ricardo Reis (Author) FMUP; Rosas, MJ (Author) Other; Monteiro, P (Author) Other; João Massano (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: JOURNAL OF CLINICAL NEUROSCIENCE

Vol. 69

Pages: 104-108

ISSN: 0967-5868

Publisher: ELSEVIER SCI LTD

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00Q-Y91

DOI: 10.1016/j.jocn.2019.08.021

Abstract (EN): This retrospective study aims to explore the clinical utility of microelectrode recording (MER) during sub thalamic deep brain stimulation (DBS) surgery in patients with Parkinson's disease (PD). We analyzed the data from 103 PD patients, who consecutively received bilateral subthalamic nucleus (STN) DBS at an experienced academic medical center. We collected demographic, clinical, and DBS related data, including intraoperative microelectrode recording data, electrode positioning, and clinical effects provided by intraoperative microstimulation. The 2 brain sides were independently analyzed and are described as first and second side (to be operated on); the first side is contralateral to motor symptoms onset. Patients were mostly men (64.1%). In both sides of the brain, percentage of agreement with the electrode final position was higher with clinical results than with intraoperative microelectrode recordings (98% vs 57% on the first implantation side, and 97% vs 58% on the second implantation side, respectively). Regarding electrode final implantation depth, 86% of electrodes were implanted between 0 mm and +2 mm in relation to anatomical target, and 95% of electrodes were implanted from 2 mm to +2 mm. Our study suggests that MER might not be necessary to achieve good clinical outcomes in PD patients undergoing STN DBS. These results support and inform the design of future prospective controlled research studies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5