Electrochemical Immunosensor for TNF alpha-Mediated Inflammatory Disease Screening

• Type: Article in International Scientific Journal
• Date: 2019-06-19

Authors

Joana Guimaraes (Author) FMUP

Journal

Title: Acs Chemical Neuroscience

Vol. 10

Pages: 2676-2682

ISSN: 1948-7193

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-00Q-K5Y

DOI: 10.1021/acschemneuro.9b00036

Abstract (EN): Inflammation associated with cancer, neuro-degenerative, ocular, and autoimmune diseases has a considerable impact on public health. Tumor necrosis factor alpha (TNF alpha) is a key mediator of inflammatory responses, responsible for many of the systemic manifestations during the inflammatory process. Thus, inhibition of TNF alpha is a commonplace practice in the treatment of these disorders. Successful therapy requires the ability to determine the appropriate dose of anti-TNF alpha drugs to be administered in a timely manner, based on circulating TNF alpha levels. In this Letter, we report the development of an immunosensor technology able to quantify TNF alpha at the picogram level in relevant human body fluids, holding the potential to early detect inflammation and monitor TNF alpha levels during treatment, enabling TNF alpha-targeted treatments to be tailored according to the immune status of an individual patient. This immunosensor technology is significantly more rapid and sensitive than conventional enzyme linked immunosorbent assays, maintaining high specificity and requiring small sample volumes. These features might also be advantageous in the context of personalized medicine, as this analytical platform can deliver advanced diagnostics and reduce clinical burden.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13