Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Penna, C (Author) Other; Andreadou, I (Author) Other; Aragno, M (Author) Other; Beauloye, C (Author) Other; Bertrand, L (Author) Other; Lazou, A (Author) Other; Falcao Pires, I (Author) FMUP; Bell, R (Author) Other; Zuurbier, CJ (Author) Other; Pagliaro, P (Author) Other; Hausenloy, DJ (Author) Other

Journal

Title: British Journal of Pharmacology

ISSN: 0007-1188

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 49 Citations

Scopus - 57 Citations

Other information

Authenticus ID: P-00R-WYR

DOI: 10.1111/bph.14993

Abstract (EN): Diabetic patients are at increased risk of developing coronary artery disease and experience worse clinical outcomes following acute myocardial infarction. Novel therapeutic strategies are required to protect the myocardium against the effects of acute ischaemia-reperfusion injury (IRI). These include one or more brief cycles of non-lethal ischaemia and reperfusion prior to the ischaemic event (ischaemic preconditioning [IPC]) or at the onset of reperfusion (ischaemic postconditioning [IPost]) either to the heart or to extracardiac organs (remote ischaemic conditioning [RIC]). Studies suggest that the diabetic heart is resistant to cardioprotective strategies, although clinical evidence is lacking. We overview the available animal models of diabetes, investigating acute myocardial IRI and cardioprotection, experiments investigating the effects of hyperglycaemia on susceptibility to acute myocardial IRI, the response of the diabetic heart to cardioprotective strategies e.g. IPC, IPost and RIC. Finally we highlight the effects of anti-hyperglycaemic agents on susceptibility to acute myocardial IRI and cardioprotection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 24