The European Phenylketonuria Guidelines and the challenges on management practices in Portugal

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Sousa, C (Author) Other; Almeida, MF (Author) Other; Barbosa, CS (Author) Other; Martins, E (Author) Other; Janeiro, P (Author) Other; de Almeida, IT (Author) Other; MacDonald, A (Author) Other; rocha, jc (Author) Other

Journal

Title: Journal of Pediatric Endocrinology and Metabolism

Vol. 32 No. 3

Pages: 623-629

ISSN: 0334-018X

Publisher: Walter De Gruyter

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-00Q-Q2T

DOI: 10.1515/jpem-2018-0527

Abstract (EN): Background: Phenylketonuria (PKU) management practices differ between and within countries. In 2007, the Portuguese Society for Metabolic Disorders (SPDM) approved the Portuguese Consensus (PC) for the nutritional treatment of PKU. The recently published European PKU Guidelines (EPG, 2017) systematically reviewed recent evidence and aimed to harmonise treatment protocols in Europe. The objective of this study was to appraise the EPG acceptance and implementation in Portuguese treatment centres. Methods: An electronic questionnaire was prepared and the link was sent to 135 SPDM members. It outlined the 10 EPG key recommendations and compared each statement with the consensus recommendations published by SPDM. Responses were recorded and descriptive analyses were performed. Results: Twenty-five professionals completed the questionnaire, and over half (56%) were nutritionists/dieticians. At least one questionnaire from each of the 10 national treatment centres was returned. In general, responders accepted most of the recommendations. However, only the recommendation about target phenylalanine (Phe) concentrations between 120 and 360 mu mol/L for patients <12 years received 100% consensus with a further seven recommendations gaining over 70% consensus. Almost half of the professionals (48%, n =12) required further discussion about the EPG-safe upper target blood Phe concentration (600 mu mol/L) suggested for patients aged >= 12 years. Almost one third (32%, n = 8) failed to agree with the recommendation in the EPG-proposed classification of Phe hydroxylase (PAH) deficiency. Conclusions: The EPG received overall good acceptance, but there was divided opinion about some recommendations which require further discussion before implementation by the Portuguese treatment centres.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7