Chronic Ingestion of High-Fat Diet and Energy Restriction Modulates Expression of VEGF and VEGFR2 in Aged Rat Myocardium

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Fernandes, D (Author) Other; Tomada, I (Author) Other; Almeida, Henrique (Author) FMUP; D Neves (Author) FMUP

Journal

Title: Microscopy and Microanalysis

Vol. 18

Pages: 7-8

ISSN: 1431-9276

Publisher: Cambridge University Press

Indexing

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Other information

Authenticus ID: P-002-72W

DOI: 10.1017/s143192761201269x

Abstract (EN): Cardiovascular diseases (CVD) constitute a leading cause of death in the aged population. Regular intake of hyperlipidic diet and obesity can induce endothelial dysfunction that precedes the onset of atherosclerosis and CVD. High-fat diet regular consumption leads to structural modifications in heart tissue, and changes in the expression of angiogenic factors and their specific receptors. Hence, we aimed to characterize the expression pattern of vascular endothelial growth factor (VEGF) and its membrane receptor VEGFR 2 in young and aged rat hearts under high-fat diet and energy restriction. © Microscopy Society of America 2012.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 2