Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Pedro Gomes (Author) FMUP; Leal, H (Author) Other; Mendes, AF (Author) Other; Reis, F (Author) Other; Cavadas, C (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: TRENDS IN PHARMACOLOGICAL SCIENCES

Vol. 40

Pages: 1021-1039

ISSN: 0165-6147

Publisher: Elsevier Science

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-00R-D9Z

DOI: 10.1016/j.tips.2019.09.003

Abstract (EN): Sirtuins (SIRT1-7), a class of NAD(+)-dependent deacylases, are central regulators of metabolic homeostasis and stress responses. While numerous salutary effects associated with sirtuin activation, especially SIRT1, are well documented, other reports show health benefits resulting from sirtuin inhibition. Furthermore, conflicting findings have been obtained regarding the patho-physiological role of specific sirtuin isoforms, suggesting that sirtuins act as 'double-edged swords'. Here, we provide an integrated overview of the different findings on the role of mammalian sirtuins in neurodegenerative and cardiometabolic disorders and attempt to dissect the reasons behind these different effects. Finally, we discuss how addressing these obstacles may provide a better understanding of the complex sirtuin biology and improve the likelihood of identifying effective and selective drug targets for a variety of human disorders.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19