Dietary fatty acids modulation of human colon cancer cells: mechanisms and future perspectives

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Brandao, D (Author) Other; ribeiro, l (Author) FMUP

Journal

Title: International Journal of Food Sciences and Nutrition

Vol. 69

Pages: 437-450

ISSN: 0963-7486

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-00W-V0Y

DOI: 10.1080/09637486.2017.1382456

Abstract (EN): Colorectal cancer (CRC) is one of the most common malignancies worldwide and its pathogenesis is proven to be related with dietary patterns, namely dietary fatty acid (FA) intake. We reviewed the evidences regarding the effect of different dietary FAs on human CRC cell lines proliferation and apoptosis. Altogether, the results obtained from in vitro studies show that monounsaturated FAs lack evidence regarding both proliferation and apoptosis, whereas there is a consensus about the anti-proliferative and pro-apoptotic effects, involving different intracellular targets, of n-3 polyunsaturated FAs, while n-6 series show a similar effect or no effects. The response to these dietary components depends on the cell type as well as the amount and duration of exposure. These results highlight the importance of identifying molecular targets for dietary components aiming to interfere with one of the main risk factors related with CRC incidence and prevalence.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14