Predictive biomarkers of bacillus Calmette-Guérin immunotherapy response in bladder cancer: Where are we now?

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Lima, L (Author) Other; Mario Dinis Ribeiro (Author) FMUP; Longatto Filho, A (Author) Other; Lucio Lara Santos (Author) ICBAS

Journal

Title: Advances in Urology

Vol. 2012

Pages: 1-17

ISSN: 1687-6369

Publisher: Hindawi

Indexing

Scopus - 24 Citations

Other information

Authenticus ID: P-008-649

DOI: 10.1155/2012/232609

Abstract (EN): The most effective therapeutic option for managing nonmuscle invasive bladder cancer (NMIBC), over the last 30 years, consists of intravesical instillations with the attenuated strain Bacillus Calmette-Guérin (the BCG vaccine). This has been performed as an adjuvant therapeutic to transurethral resection of bladder tumour (TURBT) and mostly directed towards patients with high-grade tumours, T1 tumours, and in situ carcinomas. However, from 20 to 40 of the patients do not respond and frequently present tumour progression. Since BCG effectiveness is unpredictable, it is important to find consistent biomarkers that can aid either in the prediction of the outcome and/or side effects development. Accordingly, we conducted a systematic critical review to identify the most preeminent predictive molecular markers associated with BCG response. To the best of our knowledge, this is the first review exclusively focusing on predictive biomarkers for BCG treatment outcome. Using a specific query, 1324 abstracts were gathered, then inclusion/exclusion criteria were applied, and finally 87 manuscripts were included. Several molecules, including CD68 and genetic polymorphisms, have been identified as promising surrogate biomarkers. Combinatory analysis of the candidate predictive markers is a crucial step to create a predictive profile of treatment response. © 2012 Luís Lima et al.

Language: English

Type (Professor's evaluation): Scientific