Portuguese Observational Study of Ischaemic Stroke in Patients Medicated with Non-Vitamin K Antagonist Oral Anticoagulants

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Beato Coelho, J (Author) Other; Marto, JP (Author) Other; Alves, JN (Author) Other; Marques Matos, C (Author) Other; Calado, S (Author) Other; Araújo JP (Author) FMUP; Cunha, L (Author) Other; Pinho, J (Author) Other; Azevedo, E (Author) Other; Viana Baptista, M (Author) Other; Sargento Freitas, J (Author) Other

Journal

Title: European Neurology

Vol. 79

Pages: 108-112

ISSN: 0014-3022

Publisher: Karger

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-00N-SEK

DOI: 10.1159/000486755

Abstract (EN): Introduction: Clinical trials and subsequent meta-analyses showed advantages of non-vitamin K antagonists oral anticoagulants (NOACs) over vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation. The impact of pre-admission anticoagulation in acute ischaemic stroke (AIS) has not been established. Objective: To compare functional outcome of patients with AIS with preadmission NOACs vs. VKAs. Methods: A retrospective analysis was conducted on consecutive AIS patients under oral anticoagulation (VKAs or NOACs) admitted in 4 Portuguese hospitals within a period of 30 months. Two primary outcomes were defined and compared between VKA and NOAC groups: symptomatic intracerebral hemorrhage transformation (sICH) and modified Rankin Scale (mRS) at 3 months. Results: Four hundred sixty- nine patients were included, of whom 332 (70.8%) were treated with VKA and 137 (29.2%) with NOAC. Patients' median age was 78.0 and 234 (49.9%) were male. NOAC-treated patients had a higher median CHA(2)DS(2)-VASc score than those under VKA (5.0 vs. 4.0, p = 0.023). The two primary outcomes showed no statistical differences between the VKAs' group and the NOACs' group (sICH: 5.4 vs. 5.4% [p = 0.911]; mRS at 3 months: 3.0 vs. 3.0 [p = 0.646], respectively). Conclusion: Preadmission anticoagulation with NOACs in AIS has a functional impact similar to that of VKAs. (C) 2018 S. Karger AG, Basel

Language: English

Type (Professor's evaluation): Dissemination

No. of pages: 5