Unravelling the interplay between hyperkalaemia, renin-angiotensin-aldosterone inhibitor use and clinical outcomes. Data from 9222 chronic heart failure patients of the ESC-HFA-EORP Heart Failure Long-Term Registry

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Garrido¿Lestache, EB (Author) Other; Pinilla, JG (Author) Other; Villa, BG (Author) Other; Sahuquillo, A (Author) Other; Marques, RB (Author) Other; Calvo, FT (Author) Other; Perez¿Martinez, M (Author) Other; Gracia¿Rodenas, M (Author) Other; Garrido¿Bravo, IP (Author) Other; Pastor¿Perez, F (Author) Other; Pascual¿Figal, D (Author) Other; Molina, BD (Author) Other; Orus, J (Author) Other; Gonzalo, FE (Author) Other; Bertomeu, V (Author) Other; Valero, R (Author) Other; Martinez¿Abellan, R (Author) Other; Quiles, J (Author) Other; Rodrigez¿Ortega, J (Author) Other; Mateo, I (Author) Other; ElAmrani, A (Author) Other; Fernandez¿Vivancos, C (Author) Other; Valero, DB (Author) Other; Almenar¿Bonet, L (Author) Other; Sanchez¿Lazaro, I (Author) Other; Marques¿Sule, E (Author) Other; Facila¿Rubio, L (Author) Other; Perez¿Silvestre, J (Author) Other; Garcia¿Gonzalez, P (Author) Other; Ridocci¿Soriano, F (Author) Other; Garcia¿Escriva, D (Author) Other; Pellicer¿Cabo, A (Author) Other; Fuente Galan, L (Author) Other; Diaz, JL (Author) Other; Platero, AR (Author) Other; Arias, J (Author) Other; Blasco¿Peiro, T (Author) Other; Julve, MS (Author) Other; Sanchez¿Insa, E (Author) Other; Aured¿Guallar, C (Author) Other; Portoles¿Ocampo, A (Author) Other; Melin, M (Author) Other; Hägglund, E (Author) Other; Stenberg, A (Author) Other; Lindahl, I (Author) Other; Asserlund, B (Author) Other; Olsson, L (Author) Other; Dahlström, U (Author) Other; Afzelius, M (Author) Other; Karlström, P (Author) Other; Tengvall, L (Author) Other; Olsson, B (Author) Other; Kalayci, S (Author) Other; Temizhan, A (Author) Other; Cavusoglu, Y (Author) Other; Gencer, E (Author) Other; Yilmaz, M (Author) Other; Gunes, H (Author) Other; Sosnowska¿Pasiarska, B (Author) Other; Wozakowska¿Kaplon, B (Author) Other; Krzeminski, A (Author) Other; Zabojszcz, M (Author) Other; Mirek¿Bryniarska, E (Author) Other; Grzegorzko, A (Author) Other; Bury, K (Author) Other; Nessler, J (Author) Other; Zalewski, J (Author) Other; Furman, A (Author) Other; Broncel, M (Author) Other; Poliwczak, A (Author) Other; Bala, A (Author) Other; Zycinski, P (Author) Other; Rudzinska, M (Author) Other; Jankowski, L (Author) Other; Kasprzak, J (Author) Other; Michalak, L (Author) Other; Soska, KW (Author) Other; Drozdz, J (Author) Other; Huziuk, I (Author) Other; Retwinski, A (Author) Other; Flis, P (Author) Other; Weglarz, J (Author) Other; Bodys, A (Author) Other; Grajek, S (Author) Other; Kaluzna¿Oleksy, M (Author) Other; Straburzynska¿Migaj, E (Author) Other; Dankowski, R (Author) Other; Szymanowska, K (Author) Other; Grabia, J (Author) Other; Szyszka, A (Author) Other; Nowicka, A (Author) Other; Samcik, M (Author) Other; Wolniewicz, L (Author) Other; Baczynska, K (Author) Other; Komorowska, K (Author) Other; Poprawa, I (Author) Other; Komorowska, E (Author) Other; Sajnaga, D (Author) Other; Zolbach, A (Author) Other; Dudzik¿Plocica, A (Author) Other; Abdulkarim, A (Author) Other; Lauko¿Rachocka, A (Author) Other; Kaminski, L (Author) Other; Kostka, A (Author) Other; Cichy, A (Author) Other; Ruszkowski, P (Author) Other; Splawski, M (Author) Other; Fitas, G (Author) Other; Szymczyk, A (Author) Other; Serwicka, A (Author) Other; Fiega, A (Author) Other; Zysko, D (Author) Other; Krysiak, W (Author) Other; Szabowski, S (Author) Other; Skorek, E (Author) Other; Pruszczyk, P (Author) Other; Bienias, P (Author) Other; Ciurzynski, M (Author) Other; Welnicki, M (Author) Other; Mamcarz, A (Author) Other; Folga, A (Author) Other; Zielinski, T (Author) Other; Rywik, T (Author) Other; Leszek, P (Author) Other; Sobieszczanska¿Malek, M (Author) Other; Piotrowska, M (Author) Other; Kozar¿Kaminska, K (Author) Other; Komuda, K (Author) Other; Wisniewska, J (Author) Other; Tarnowska, A (Author) Other; Balsam, P (Author) Other; Marchel, M (Author) Other; Opolski, G (Author) Other; Kaplon¿Cieslicka, A (Author) Other; Gil, R (Author) Other; Mozenska, O (Author) Other; Byczkowska, K (Author) Other; Gil, K (Author) Other; Pawlak, A (Author) Other; Michalek, A (Author) Other; Krzesinski, P (Author) Other; Piotrowicz, K (Author) Other; Uzieblo¿Zyczkowska, B (Author) Other; Stanczyk, A (Author) Other; Skrobowski, A (Author) Other; Ponikowski, P (Author) Other; Jankowska, E (Author) Other; Rozentryt, P (Author) Other; Polonski, L (Author) Other; Gadula¿Gacek, E (Author) Other; Nowalany¿Kozielska, E (Author) Other; Kuczaj, A (Author) Other; Kalarus, Z (Author) Other; Szulik, M (Author) Other; Przybylska, K (Author) Other; Klys, J (Author) Other; Prokop¿Lewicka, G (Author) Other; Kleinrok, A (Author) Other; Aguiar, CT (Author) Other; Ventosa, A (Author) Other; Pereira, S (Author) Other; Faria, R (Author) Other; Chin, J (Author) Other; De Jesus, I (Author) Other; Santos, R (Author) Other; Silva, P (Author) Other; Moreno, N (Author) Other; Queirós, C (Author) Other; Lourenço, C (Author) Other; Pereira, A (Author) Other; Castro, A (Author) Other; Andrade, A (Author) Other; Guimaraes, TO (Author) Other; Martins, S (Author) Other; Placido, R (Author) Other; Lima, G (Author) Other; Brito, D (Author) Other; Francisco, A (Author) Other; Cardiga, R (Author) Other; Proenca, M (Author) Other; Araujo, I (Author) Other; Marques, F (Author) Other; Fonseca, C (Author) Other; Moura, B (Author) Other; Leite, S (Author) Other; Campelo, M (Author) FMUP; Silva¿Cardoso, J (Author) Other; Rodrigues, J (Author) Other; Rangel, I (Author) Other; Martins, E (Author) Other; Correia, AS (Author) Other; Peres, M (Author) Other; Marta, L (Author) Other; Silva, GF (Author) Other; Severino, D (Author) Other; Durao, D (Author) Other; Leao, S (Author) Other; Magalhaes, P (Author) Other; Moreira, I (Author) Other; Cordeiro, AF (Author) Other; Ferreira, C (Author) Other; Araujo, C (Author) Other; Ferreira, A (Author) Other; Baptista, A (Author) Other; Radoi, M (Author) Other; Bicescu, G (Author) Other; Vinereanu, D (Author) Other; Sinescu, C (Author) Other; Macarie, C (Author) Other; Popescu, R (Author) Other; Daha, I (Author) Other; Dan, G (Author) Other; Stanescu, C (Author) Other; Dan, A (Author) Other; Craiu, E (Author) Other; Nechita, E (Author) Other; Aursulesei, V (Author) Other; Christodorescu, R (Author) Other; Otasevic, P (Author) Other; Seferovic, P (Author) Other; Simeunovic, D (Author) Other; Ristic, A (Author) Other; Celic, V (Author) Other; Pavlovic¿Kleut, M (Author) Other; Lazic, JS (Author) Other; Stojcevski, B (Author) Other; Pencic, B (Author) Other; Stevanovic, A (Author) Other; Andric, A (Author) Other; Simi¿, D (Author) Other; A¨anin, M (Author) Other; Iric¿Cupic, V (Author) Other; Jovic, M (Author) Other; Davidovic, G (Author) Other; Milanov, S (Author) Other; Mitic, V (Author) Other; Atanaskovic, V (Author) Other; Antic, S (Author) Other; Pavlovic, M (Author) Other; Stanojevic, D (Author) Other; Stoickov, V (Author) Other; Ilic, S (Author) Other; Ilic, MD (Author) Other; Petrovic, D (Author) Other; Stojsic, S (Author) Other; Kecojevic, S (Author) Other; Dodic, S (Author) Other; Adic, NC (Author) Other; Cankovic, M (Author) Other; Stojiljkovic, J (Author) Other; Mihajlovic, B (Author) Other; Radin, A (Author) Other; Radovanovic, S (Author) Other; Krotin, M (Author) Other; Klabnik, A (Author) Other; Goncalvesova, E (Author) Other; Pernicky, M (Author) Other; Murin, J (Author) Other; Kovar, F (Author) Other; Kmec, J (Author) Other; Semjanova, H (Author) Other; Strasek, M (Author) Other; Iskra, MS (Author) Other; Ravnikar, T (Author) Other; Suligoj, NC (Author) Other; Komel, J (Author) Other; Fras, Z (Author) Other; Jug, B (Author) Other; Glavic, T (Author) Other; Losic, R (Author) Other; Bombek, M (Author) Other; Krajnc, I (Author) Other; Krunic, B (Author) Other; Horvat, S (Author) Other; Kovac, D (Author) Other; Rajtman, D (Author) Other; Cencic, V (Author) Other; Letonja, M (Author) Other; Winkler, R (Author) Other; Valentincic, M (Author) Other; Melihen¿Bartolic, C (Author) Other; Bartolic, A (Author) Other; Vrckovnik, MP (Author) Other; Kladnik, M (Author) Other; Pusnik, CS (Author) Other; Marolt, A (Author) Other; Klen, J (Author) Other; Drnovsek, B (Author) Other; Leskovar, B (Author) Other; Anguita, MF (Author) Other; Page, JG (Author) Other; Martinez, FS (Author) Other; Andres, J (Author) Other; Bayes¿Genis, A (Author) Other; Mirabet, S (Author) Other; Mendez, A (Author) Other; Garcia¿Cosio, L (Author) Other; Roig, E (Author) Other; Leon, V (Author) Other; Gonzalez¿Costello, J (Author) Other; Muntane, G (Author) Other; Garay, A (Author) Other; Alcade¿Martinez, V (Author) Other; Fernandez, SL (Author) Other; Rivera¿Lopez, R (Author) Other; Puga¿Martinez, M (Author) Other; Fernandez¿Alvarez, M (Author) Other; Serrano¿Martinez, J (Author) Other; Crespo¿Leiro, M (Author) Other; Grille¿Cancela, Z (Author) Other; Marzoa¿Rivas, R (Author) Other; Blanco¿Canosa, P (Author) Other; Paniagua¿Martin, M (Author) Other; Barge¿Caballero, E (Author) Other; Cerdena, IL (Author) Other; Baldomero, IFH (Author) Other; Padron, AL (Author) Other; Rosillo, SO (Author) Other; Gonzalez¿Gallarza, RD (Author) Other; Montanes, OS (Author) Other; Manjavacas, AI (Author) Other; Conde, AC (Author) Other; Araujo, A (Author) Other; Soria, T (Author) Other; Garcia¿Pavia, P (Author) Other; Gomez¿Bueno, M (Author) Other; Cobo¿Marcos, M (Author) Other; Alonso¿Pulpon, L (Author) Other; Cubero, JS (Author) Other; Sayago, I (Author) Other; Gonzalez¿Segovia, A (Author) Other; Briceno, A (Author) Other; Subias, PE (Author) Other; Hernandez, MV (Author) Other; Cano, MR (Author) Other; Sanchez, MG (Author) Other; Jimenez, JD (Author) Other; Rossignol, P (Author) Other; Lainscak, M (Author) Other; Crespo¿Leiro, MG (Author) Other; Laroche, C (Author) Other; Piepoli, MF (Author) Other; Filippatos, G (Author) Other; Rosano, GM (Author) Other; Savarese, G (Author) Other; Anker, SD (Author) Other; Seferovic, PM (Author) Other; Ruschitzka, F (Author) Other; Coats, AJ (Author) Other; Mebazaa, A (Author) Other; McDonagh, T (Author) Other; Sahuquillo, A (Author) Other; Penco, M (Author) Other; Maggioni, AP (Author) Other; Lund, LH (Author) Other; Christopher Peter Gale, G (Author) Other; Branko Beleslin, R (Author) Other; Andrzej Budaj, P (Author) Other; Ovidiu Chioncel, R (Author) Other; Nikolaos Dagres, D (Author) Other; Nicolas Danchin, F (Author) Other; David Erlinge, S (Author) Other; Jonathan Emberson, G (Author) Other; Michael Glikson, I (Author) Other; Alastair Gray, G (Author) Other; Meral Kayikcioglu, T (Author) Other; Aldo Maggioni, I (Author) Other; Klaudia Vivien Nagy, H (Author) Other; Aleksandr Nedoshivin, R (Author) Other; Anna¿Sonia Petronio, I (Author) Other; Jolien Roos¿Hesselink, N (Author) Other; Lars Wallentin, S (Author) Other; Uwe Zeymer, D (Author) Other; Crespo¿Leiro, M (Author) Other; Anker, S (Author) Other; Mebazaa, A (Author) Other; Coats, A (Author) Other; Filippatos, G (Author) Other; Ferrari, R (Author) Other; Maggioni, A (Author) Other; Piepoli, M (Author) Other; Goda, A (Author) Other; Diez, M (Author) Other; Fernandez, A (Author) Other; Fruhwald, F (Author) Other; Fazlibegovic, E (Author) Other; Gatzov, P (Author) Other; Kurlianskaya, A (Author) Other; Hullin, R (Author) Other; Christodoulides, T (Author) Other; Hradec, J (Author) Other; Nielsen, OW (Author) Other; Nedjar, R (Author) Other; Uuetoa, T (Author) Other; Hassanein, M (Author) Other; Jimenez, JFD (Author) Other; Harjola, V (Author) Other; Logeart, D (Author) Other; Chumburidze, V (Author) Other; Tousoulis, D (Author) Other; Milicic, D (Author) Other; Merkely, B (Author) Other; O'Donoghue, E (Author) Other; Amir, O (Author) Other; Shotan, A (Author) Other; Shafie, D (Author) Other; Metra, M (Author) Other; Matsumori, A (Author) Other; Mirrakhimov, E (Author) Other; Kavoliuniene, A (Author) Other; Erglis, A (Author) Other; Vataman, E (Author) Other; Otljanska, M (Author) Other; Kostovska, ES (Author) Other; DeMarco, DC (Author) Other; Drozdz, J (Author) Other; Fonseca, C (Author) Other; Chioncel, O (Author) Other; Dekleva, M (Author) Other; Shkolnik, E (Author) Other; Dahlstrom, U (Author) Other; Lainscak, M (Author) Other; Goncalvesova, E (Author) Other; Temizhan, A (Author) Other; Estrago, V (Author) Other; 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El Messiry, F (Author) Other; El Shazly, A (Author) Other; Elrakshy, Y (Author) Other; Youssef, A (Author) Other; Moneim, A (Author) Other; Noamany, M (Author) Other; Reda, A (Author) Other; Dayem, TA (Author) Other; Farag, N (Author) Other; Halawa, SI (Author) Other; Hamid, MA (Author) Other; Said, K (Author) Other; Saleh, A (Author) Other; Ebeid, H (Author) Other; Hanna, R (Author) Other; Aziz, R (Author) Other; Louis, O (Author) Other; Enen, M (Author) Other; Ibrahim, B (Author) Other; Nasr, G (Author) Other; Elbahry, A (Author) Other; Sobhy, H (Author) Other; Ashmawy, M (Author) Other; Gouda, M (Author) Other; Aboleineen, W (Author) Other; Bernard, Y (Author) Other; Luporsi, P (Author) Other; Meneveau, N (Author) Other; Pillot, M (Author) Other; Morel, M (Author) Other; Seronde, M (Author) Other; Schiele, F (Author) Other; Briand, F (Author) Other; Delahaye, F (Author) Other; Damy, T (Author) Other; Eicher, J (Author) Other; Groote, P (Author) Other; Fertin, M (Author) Other; Lamblin, N (Author) Other; Isnard, R (Author) Other; Lefol, C (Author) Other; Thevenin, S (Author) Other; Hagege, A (Author) Other; Jondeau, G (Author) Other; Logeart, D (Author) Other; Le Marcis, V (Author) Other; Ly, J (Author) Other; Coisne, D (Author) Other; Lequeux, B (Author) Other; Le Moal, V (Author) Other; Mascle, S (Author) Other; Lotton, P (Author) Other; Behar, N (Author) Other; Donal, E (Author) Other; Thebault, C (Author) Other; Ridard, C (Author) Other; Reynaud, A (Author) Other; Basquin, A (Author) Other; Bauer, F (Author) Other; Codjia, R (Author) Other; Galinier, M (Author) Other; Tourikis, P (Author) Other; Stavroula, M (Author) Other; Tousoulis, D (Author) Other; Stefanadis, C (Author) Other; Chrysohoou, C (Author) Other; Kotrogiannis, I (Author) Other; Matzaraki, V (Author) Other; Dimitroula, T (Author) Other; Karavidas, A (Author) Other; Tsitsinakis, G (Author) Other; Kapelios, C (Author) Other; Nanas, J (Author) Other; Kampouri, H (Author) Other; Nana, E (Author) Other; Kaldara, E (Author) Other; Eugenidou, A (Author) Other; Vardas, P (Author) Other; Saloustros, I (Author) Other; Patrianakos, A (Author) Other; Tsaknakis, T (Author) Other; Evangelou, S (Author) Other; Nikoloulis, N (Author) Other; Tziourganou, H (Author) Other; Tsaroucha, A (Author) Other; Papadopoulou, A (Author) Other; Douras, A (Author) Other; Polgar, L (Author) Other; Merkely, B (Author) Other; Kosztin, A (Author) Other; Nyolczas, N (Author) Other; Nagy, AC (Author) Other; Halmosi, R (Author) Other; Elber, J (Author) Other; Alony, I (Author) Other; Shotan, A (Author) Other; Fuhrmann, AV (Author) Other; Amir, O (Author) Other; Romano, S (Author) Other; Marcon, S (Author) Other; Penco, M (Author) Other; Di Mauro, M (Author) Other; Lemme, E (Author) Other; Carubelli, V (Author) Other; Rovetta, R (Author) Other; Metra, M (Author) Other; Bulgari, M (Author) Other; Quinzani, F (Author) Other; Lombardi, C (Author) Other; Bosi, S (Author) Other; Schiavina, G (Author) Other; Squeri, A (Author) Other; Barbieri, A (Author) Other; Di Tano, G (Author) Other; Pirelli, S (Author) Other; Ferrari, R (Author) Other; Fucili, A (Author) Other; Passero, T (Author) Other; Musio, S (Author) Other; Di Biase, M (Author) Other; Correale, M (Author) Other; Salvemini, G (Author) Other; Brognoli, S (Author) Other; Zanelli, E (Author) Other; Giordano, A (Author) Other; Agostoni, P (Author) Other; Italiano, G (Author) Other; Salvioni, E (Author) Other; Copelli, S (Author) Other; Modena, M (Author) Other; Reggianini, L (Author) Other; Valenti, C (Author) Other; Olaru, A (Author) Other; Bandino, S (Author) Other; Deidda, M (Author) Other; Mercuro, G (Author) Other; Dessalvi, CC (Author) Other; Marino, P (Author) Other; Di Ruocco, M (Author) Other; Sartori, C (Author) Other; Piccinino, C (Author) Other; Parrinello, G (Author) Other; Licata, G (Author) Other; Torres, D (Author) Other; Giambanco, S (Author) Other; Busalacchi, S (Author) Other; Arrotti, S (Author) Other; Novo, S (Author) Other; Inciardi, R (Author) Other; Pieri, P (Author) Other; Chirco, P (Author) Other; Galifi, MA (Author) Other; Teresi, G (Author) Other; Buccheri, D (Author) Other; Minacapelli, A (Author) Other; Veniani, M (Author) Other; Frisinghelli, A (Author) Other; Priori, S (Author) Other; Cattaneo, S (Author) Other; Opasich, C (Author) Other; Gualco, A (Author) Other; Pagliaro, M (Author) Other; Mancone, M (Author) Other; Fedele, F (Author) Other; Cinque, A (Author) Other; Vellini, M (Author) Other; Scarfo, I (Author) Other; Romeo, F (Author) Other; Ferraiuolo, F (Author) Other; Sergi, D (Author) Other; Anselmi, M (Author) Other; Melandri, F (Author) Other; Leci, E (Author) Other; Iori, E (Author) Other; Bovolo, V (Author) Other; Pidello, S (Author) Other; Frea, S (Author) Other; Bergerone, S (Author) Other; Botta, M (Author) Other; Canavosio, F (Author) Other; Gaita, F (Author) Other; Merlo, M (Author) Other; Cinquetti, M (Author) Other; Sinagra, G (Author) Other; Ramani, F (Author) Other; Fabris, E (Author) Other; Stolfo, D (Author) Other; Artico, J (Author) Other; Miani, D (Author) Other; Fresco, C (Author) Other; Daneluzzi, C (Author) Other; Proclemer, A (Author) Other; Cicoira, M (Author) Other; Zanolla, L (Author) Other; Marchese, G (Author) Other; Torelli, F (Author) Other; Vassanelli, C (Author) Other; Voronina, N (Author) Other; Erglis, A (Author) Other; Tamakauskas, V (Author) Other; Smalinskas, V (Author) Other; Karaliute, R (Author) Other; Petraskiene, I (Author) Other; Kazakauskaite, E (Author) Other; Rumbinaite, E (Author) Other; Kavoliuniene, A (Author) Other; Vysniauskas, V (Author) Other; Brazyte¿Ramanauskiene, R (Author) Other; Petraskiene, D (Author) Other; Stankala, S (Author) Other; Switala, P (Author) Other; Juszczyk, Z (Author) Other; Sinkiewicz, W (Author) Other; Gilewski, W (Author) Other; Pietrzak, J (Author) Other; Orzel, T (Author) Other; Kasztelowicz, P (Author) Other; Kardaszewicz, P (Author) Other; Lazorko¿Piega, M (Author) Other; Gabryel, J (Author) Other; Mosakowska, K (Author) Other; Bellwon, J (Author) Other; Rynkiewicz, A (Author) Other; Raczak, G (Author) Other; Lewicka, E (Author) Other; Dabrowska¿Kugacka, A (Author) Other; Bartkowiak, R (Author) Other

Journal

Title: European Journal of Heart Failure

Vol. 22

Pages: 1378-1389

ISSN: 1388-9842

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 48 Citations

Scopus - 46 Citations

Other information

Authenticus ID: P-00V-ZVF

DOI: 10.1002/ejhf.1793

Abstract (EN): Aims We assessed the interplay between hyperkalaemia (HK) and renin-angiotensin-aldosterone system inhibitor (RAASi) use, dose and discontinuation, and their association with all-cause or cardiovascular death in patients with chronic heart failure (HF). We hypothesized that HK-associated increased death may be related to RAASi withdrawal. Methods and results The ESC-HFA-EORP Heart Failure Long-Term Registry was used. Among 9222 outpatients (HF with reduced ejection fraction: 60.6%, HF with mid-range ejection fraction: 22.9%, HF with preserved ejection fraction: 16.5%) from 31 countries, 16.6% had HK (>= 5.0 mmol/L) at baseline. Angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) was used in 88.3%, a mineralocorticoid receptor antagonist (MRA) in 58.7%, or a combination in 53.2%; of these, at >= 50% of target dose in ACEi: 61.8%; ARB: 64.7%; and MRA: 90.3%. At a median follow-up of 12.2 months, there were 789 deaths (8.6%). Both hypokalaemia and HK were independently associated with higher mortality, and ACEi/ARB prescription at baseline with lower mortality. MRA prescription was not retained in the model. In multivariable analyses, HK at baseline was independently associated with MRA non-prescription at baseline and subsequent discontinuation. When considering subsequent discontinuation of RAASi (instead of baseline use), HK was no longer found associated with all-cause deaths. Importantly, all RAASi (ACEi, ARB, or MRA) discontinuations were strongly associated with mortality. Conclusions In HF, hyper- and hypokalaemia were associated with mortality. However, when adjusting for RAASi discontinuation, HK was no longer associated with mortality, suggesting that HK may be a risk marker for RAASi discontinuation rather than a risk factor for worse outcomes.

Language: English

Type (Professor's evaluation): Dissemination

No. of pages: 12