Physicians' guideline adherence is associated with long-term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Komajda, M (Author) Other; Schöpe, J (Author) Other; Wagenpfeil, S (Author) Other; Tavazzi, L (Author) Other; Böhm, M (Author) Other; Ponikowski, P (Author) Other; Anker, SD (Author) Other; Filippatos, GS (Author) Other; Cowie, MR (Author) Other; Aleksanyan, A (Author) Other; Atayan, L (Author) Other; Avetisyan, A (Author) Other; Davtyan, N (Author) Other; Drambyan, M (Author) Other; Gevorgyan, K (Author) Other; Grigoryan, M (Author) Other; Hakobyan, Z (Author) Other; Hayrapetyan, H (Author) Other; Kocharyan, L (Author) Other; Kramarevskaya, T (Author) Other; Melqonyan, A (Author) Other; Muradyan, F (Author) Other; Nanyan, R (Author) Other; Ordyan, A (Author) Other; Ordyan, M (Author) Other; Piruzyan, A (Author) Other; Podosyan, G (Author) Other; Safaryan, K (Author) Other; Sargsyan, T (Author) Other; Sarkisyan, A (Author) Other; Sisakyan, H (Author) Other; Ter¿Grigoryan, V (Author) Other; Ustyan, T (Author) Other; Alexopoulos, C (Author) Other; Amerena, J (Author) Other; Arstall, M (Author) Other; Ayres, B (Author) Other; Barron, G (Author) Other; Beltrame, J (Author) Other; Bou¿Samra, J (Author) Other; Brown, M (Author) Other; Cross, D (Author) Other; Dwyer, N (Author) Other; Eccleston, N (Author) Other; Hare, D (Author) Other; Ho, B (Author) Other; Hopper, I (Author) Other; Jackson, B (Author) Other; Korczyk, D (Author) Other; Lattimore, J (Author) Other; Levendel, A (Author) Other; Macfadyen, R (Author) Other; Pandeli, V (Author) Other; Playford, D (Author) Other; Richardson, M (Author) Other; Senior, JA (Author) Other; Shah, A (Author) Other; Shetty, P (Author) Other; Soward, A (Author) Other; Srivastava, P (Author) Other; Swale, M (Author) Other; Vogl, E (Author) Other; Wai, B (Author) Other; William, M (Author) Other; Worthington, A (Author) Other; Wright, S (Author) Other; Brunner, B (Author) Other; Fuhrmann, W (Author) Other; Horer, L (Author) Other; Maca, T (Author) Other; Nahler, A (Author) Other; Ortner, H (Author) Other; Racz, G (Author) Other; Scheibner, P (Author) Other; Sebald, C (Author) Other; Abdullayev, A (Author) Other; Abdullayev, R (Author) Other; Ahmadov, A (Author) Other; Alakbarov, E (Author) Other; Aliyev, F (Author) Other; Aliyev, F (Author) Other; Bakhshaliyev, A (Author) Other; Bakhshiyev, M (Author) Other; Dadashova, G (Author) Other; Dashdamirov, R (Author) Other; Faradjova, N (Author) Other; Guliyev, A (Author) Other; Guliyev, F (Author) Other; Guliyeva, S (Author) Other; Hajiyev, G (Author) Other; Ibrahimov, F (Author) Other; Imanov, G (Author) Other; Isayeva, A (Author) Other; Isayeva, M (Author) Other; Jabrailova, U (Author) Other; Jafarov, R (Author) Other; Jahangirov, T (Author) Other; Khalilov, A (Author) Other; Khalilov, S (Author) Other; Mehdiyev, S (Author) Other; Najafov, R (Author) Other; Samedova, H (Author) Other; Shahhuseynov, S (Author) Other; Yusifly, R (Author) Other; Yusifov, T (Author) Other; Zahidova, K (Author) Other; Zeynalov, A (Author) Other; Abdullatif, A (Author) Other; Al¿Banna, R (Author) Other; Haiky, W (Author) Other; Husain, A (Author) Other; Jamsheer, A (Author) Other; Barbuk, O (Author) Other; Belskaya, M (Author) Other; Borodko, V (Author) Other; Kurlianskaya, A (Author) Other; Mackevich, S (Author) Other; Mankevich, N (Author) Other; Moroz¿Vodolazhskaya, N (Author) Other; Ravtovich, O (Author) Other; Saevich, A (Author) Other; Troyanova, T (Author) Other; Chughtai, A (Author) Other; Johar, S (Author) Other; Luqman, N (Author) Other; Nair, T (Author) Other; Deyoung, P (Author) Other; Ezekowitz, J (Author) Other; Frenette, M (Author) Other; Howlett, J (Author) Other; Huynh, T (Author) Other; Nguyen, V (Author) Other; Toma, M (Author) Other; Orenstein, T (Author) Other; Rinne, MRC (Author) Other; Virani, S (Author) Other; Zieroth, S (Author) Other; Ailiman, M (Author) Other; Cong, H (Author) Other; Ding, W (Author) Other; Dong, W (Author) Other; Dong, Y (Author) Other; Gao, C (Author) Other; Li, L (Author) Other; Li, Z (Author) Other; Liang, Y (Author) Other; Liu, X (Author) Other; Liu, S (Author) Other; Luo, S (Author) Other; Shi, H (Author) Other; Tian, Q (Author) Other; Wang, D (Author) Other; Wang, J (Author) Other; Wei, M (Author) Other; Wu, C (Author) Other; Xu, D (Author) Other; Yang, X (Author) Other; Yang, Z (Author) Other; Zhang, C (Author) Other; Zhang, Q (Author) Other; Zhang, Y (Author) Other; Zhang, R (Author) Other; Zheng, Y (Author) Other; Zhao, L (Author) Other; Zhou, J (Author) Other; Buch, P (Author) Other; Davidsen, F (Author) Other; Eiskjær, H (Author) Other; Bruun, NE (Author) Other; Kragh¿Thomsen, NE (Author) Other; Franow, H (Author) Other; Køber, L (Author) Other; Korup, E (Author) Other; Madsen, BK (Author) Other; Mikkelsen, K (Author) Other; Nielsen, K (Author) Other; Nørgaard, A (Author) Other; Refsgaard, J (Author) Other; Rickers, H (Author) Other; Kaiser, P (Author) Other; Sykulski, R (Author) Other; Zeuthen, E (Author) Other; El Fottoh, AA (Author) Other; El Badry, M (Author) Other; El Hady, YA (Author) Other; El Kady, E (Author) Other; El Khatib, H (Author) Other; Fawzy, M (Author) Other; Hegazy, H (Author) Other; Salama, MK (Author) Other; Mortada, A (Author) Other; Mostafa, T (Author) Other; Mwafy, A (Author) Other; Ossama, M (Author) Other; Samir, S (Author) Other; Seleem, M (Author) Other; Sobhy, B (Author) Other; Bregadze, G (Author) Other; Chelidze, K (Author) Other; Chumburidze, V (Author) Other; Jalabadze, K (Author) Other; Khabeishvili, G (Author) Other; Kiphiani, Z (Author) Other; Klimiashvili, Z (Author) Other; Kvitsiani, A (Author) Other; Mamatsashvili, M (Author) Other; Melia, IMA (Author) Other; Oragvelidze, T (Author) Other; Orjonikidze, S (Author) Other; Paposhvili, K (Author) Other; Petriashvili, S (Author) Other; Phaghava, Z (Author) Other; Shushania, M (Author) Other; Tsetskhladze, E (Author) Other; Tsinamdzgvishvili, B (Author) Other; Abdel¿Qader, M (Author) Other; Al¿Zoebi, A (Author) Other; Böhm, G (Author) Other; Bosch, R (Author) Other; Brune, S (Author) Other; Bunge, K (Author) Other; Dominick, K (Author) Other; Duda, S (Author) Other; Erdogan, A (Author) Other; Faber, G (Author) Other; Fach, C (Author) Other; Fechtrup, C (Author) Other; Frickel, S (Author) Other; Giokoglu, K (Author) Other; Haas, J (Author) Other; Hagenow, A (Author) Other; Haj¿Yehia, A (Author) Other; Hansen, C (Author) Other; Hartung, W (Author) Other; Hauser, E (Author) Other; Hofmeister, A (Author) Other; Hohensee, H (Author) Other; Hüttemann, M (Author) Other; Keim, M (Author) Other; Krämer, A (Author) Other; Langwasser, K (Author) Other; Lodde, B (Author) Other; Lorch, G (Author) Other; Lüer, C (Author) Other; Müller, K (Author) Other; Placke, J (Author) Other; Plesch, B (Author) Other; Potolidis, L (Author) Other; Richter, F (Author) Other; Rieker, W (Author) Other; Schlichting, J (Author) Other; Stenzel, G (Author) Other; Theuer, J (Author) Other; Marcin, A (Author) Other; Warkentin, R (Author) Other; Wegner, M (Author) Other; Wilke, A (Author) Other; Agrafiotis, I (Author) Other; Aleksandridis, I (Author) Other; Farmakis, D (Author) Other; Giannakoulas, G (Author) Other; Karavidas, A (Author) Other; Lamprou, A (Author) Other; Ninios, V (Author) Other; Panagiotopoulos, K (Author) Other; Papadopoulos, K (Author) Other; Siachos, S (Author) Other; Dékány, M (Author) Other; Borbéy, A (Author) Other; Borsányi, T (Author) Other; Forster, T (Author) Other; Gavallér, H (Author) Other; Gyuricza, I (Author) Other; Heltai, K (Author) Other; Herczeg, B (Author) Other; H¿gye, M (Author) Other; Losonczi, I (Author) Other; Merkely, B (Author) Other; Metz, E (Author) Other; Muk, B (Author) Other; Nagy, K (Author) Other; Ökrös, M (Author) Other; Piry, K (Author) Other; Poós, G (Author) Other; Sárszegi, Z (Author) Other; Somogyi, T (Author) Other; Sziliczei¿Németh, E (Author) Other; Tátrai, T (Author) Other; Zima, E (Author) Other; Zsigmond, A (Author) Other; Daly, C (Author) Other; Mahon, N (Author) Other; Meany, B (Author) Other; Abbdi, I (Author) Other; Awaysheh, R (Author) Other; Azouka, M (Author) Other; Hamoudeh, S (Author) Other; Nammas, A (Author) Other; Okkeh, O (Author) Other; Aimakova, G (Author) Other; Ismagulova, Z (Author) Other; Issabekova, A (Author) Other; Junusbekova, G (Author) Other; Koshumbayeva, K (Author) Other; Madaliyev, K (Author) Other; Mekebekova, D (Author) Other; Mukatova, A (Author) Other; Ospanova, G (Author) Other; Sadvakassova, G (Author) Other; Sunkarbekova, Z (Author) Other; Yegorova, Y (Author) Other; Zhangelova, S (Author) Other; Kim, K (Author) Other; Al¿Mutairi, M (Author) Other; Gaber, Y (Author) Other; Ghali, I (Author) Other; Ghanem, A (Author) Other; Hafez, H (Author) Other; Haiba, M (Author) Other; Koushy, T (Author) Other; Mahmoud, A (Author) Other; Raafat, G (Author) Other; Sallam, M (Author) Other; Senousi, O (Author) Other; Soliman, M (Author) Other; Massih, TA (Author) Other; Ali, SA (Author) Other; Jaoude, SA (Author) Other; Azzi, N (Author) Other; Badaoui, G (Author) Other; Bayeh, H (Author) Other; Beydoun, A (Author) Other; Chammas, E (Author) Other; Dib, H (Author) Other; Gebran, M (Author) Other; Ghanem, G (Author) Other; Haidar, H (Author) Other; Hamadeh, M (Author) Other; Hamoui, O (Author) Other; Hobeika, R (Author) Other; Jazra, C (Author) Other; Kabbani, S (Author) Other; Kadri, Z (Author) Other; Karanaminassian, R (Author) Other; Kassab, R (Author) Other; Kleit, M (Author) Other; Mansour, H (Author) Other; Mousallem, N (Author) Other; Semaan, C (Author) Other; Simonian, A (Author) Other; Sarkis, A (Author) Other; Succar, S (Author) Other; Zalloum, R (Author) Other; Zind, R (Author) Other; Anusauskiene, J (Author) Other; Grigaliuniene, A (Author) Other; Karaliute, R (Author) Other; Kavoliuniene, A (Author) Other; Kozlovaite, V (Author) Other; Miliuniene, D (Author) Other; Rinkuniene, D (Author) Other; Rudys, A (Author) Other; Stasaityte, D (Author) Other; Aziz, FA (Author) Other; Rahim, AA (Author) Other; Ahmad, R (Author) Other; Ahmadsah, SKA (Author) Other; Ang, C (Author) Other; Ang, S (Author) Other; Cham, Y (Author) Other; Chee, K (Author) Other; Chooi, K (Author) Other; 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Koh, K (Author) Other; Low, D (Author) Other; Abdelkhirane, C (Author) Other; Allali, Y (Author) Other; Askour, M (Author) Other; Balafrej, K (Author) Other; Bendagha, N (Author) Other; Bendriss, L (Author) Other; Benjelloun, H (Author) Other; Chaib, A (Author) Other; Cherradi, G (Author) Other; Cherti, M (Author) Other; Chtioui, M (Author) Other; El Belghiti, AR (Author) Other; Fihri, OF (Author) Other; Habbal, R (Author) Other; El Hattaoui, M (Author) Other; Khatouri, A (Author) Other; Kheyi, J (Author) Other; Kriem, J (Author) Other; Soufiane, N (Author) Other; Soufiani, A (Author) Other; Zaimi, S (Author) Other; Adamczyk¿Kot, D (Author) Other; Barg, Z (Author) Other; Bartkowiak, R (Author) Other; Braciszewicz, W (Author) Other; Czajkowska, E (Author) Other; Dudek¿Niechcia¿, M (Author) Other; Grzelakowski, P (Author) Other; Jarosik, Z (Author) Other; Jerzykowska, O (Author) Other; Koprowski, P (Author) Other; Krysiak, W (Author) Other; ¿ajkowski, Z (Author) Other; Ziemlewska¿Krawczyk, E (Author) Other; Lelonek, M (Author) Other; Lewicka, E (Author) Other; P¿onka, J (Author) Other; Sadowski, J (Author) Other; St¿pie¿¿Adamczewska, V (Author) Other; Szponar, J (Author) Other; Wrzesi¿ski, K (Author) Other; Brito, DA (Author) Other; Araújo, I (Author) Other; Figueiredo, JA (Author) Other; Campelo, M (Author) FMUP; Sardinha, PB (Author) Other; Fernando, P (Author) Other; Brito Domingues Sanches Peres de No, M (Author) Other; Baptista, SC (Author) Other; Cardoso Pinto, J (Author) Other; Piçarra, BC (Author) Other; Farto e Abreu, P (Author) Other; Fonseca, MFG (Author) Other; Soares, ACGO (Author) Other; Resende, JDA (Author) Other; Durão, D (Author) Other; Nascimento, AFV (Author) Other; Bernardes, EMO (Author) Other; Marques, F (Author) Other; Ramos, MN (Author) Other; Sargento, LM (Author) Other; Santos, JPF (Author) Other; Raimundo, A (Author) Other; Luz Ventosa, AS (Author) Other; Sarmento, P (Author) Other; Aguiar, CT (Author) Other; Ahmed, E (Author) Other; Al¿Suwaidi, J (Author) Other; 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Kuimov, A (Author) Other; Kushnarenko, N (Author) Other; Lebedev, P (Author) Other; Matushin, G (Author) Other; Mineeva, E (Author) Other; Motylev, I (Author) Other; Nedbaykin, A (Author) Other; Nevzorova, V (Author) Other; Rachkova, S (Author) Other; Rebrov, A (Author) Other; Reznik, I (Author) Other; Saiganov, S (Author) Other; Sayfutdinov, R (Author) Other; Schekotov, V (Author) Other; Serdechnaya, E (Author) Other; Shalaev, S (Author) Other; Shtegman, O (Author) Other; Sitnikova, M (Author) Other; Smolenskaya, O (Author) Other; Sulimov, V (Author) Other; Tarlovskaya, E (Author) Other; Temnikova, E (Author) Other; Timonin, D (Author) Other; Tolstov, S (Author) Other; Uskatch, T (Author) Other; Ustyuzhanin, V (Author) Other; Valeeva, R (Author) Other; Vasyuk, Y (Author) Other; Viktorova, I (Author) Other; Yakushin, S (Author) Other; Zadionchenko, V (Author) Other; Zateischikov, D (Author) Other; Zhirov, I (Author) Other; Bollová, D (Author) Other; Dulková, K (Author) Other; Fazeka¨, F (Author) Other; 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Pinar, P (Author) Other; Ta¿, M (Author) Other; Tosun, H (Author) Other; Yazlar, AS (Author) Other; Yilmaz, S (Author) Other; Yuksel, Y (Author) Other; Bagriy, A (Author) Other; Ivchyna, N (Author) Other; Lyashenko, A (Author) Other; Matviychuk, N (Author) Other; Shchukina, O (Author) Other; Tkach, N (Author) Other; Tseluyko, V (Author) Other; Vasylieva, L (Author) Other; Abdallah, A (Author) Other; Agrawal, A (Author) Other; Basleeb, F (Author) Other; Bazargani, N (Author) Other; Hatou, E (Author) Other; Al Kaddour, A (Author) Other; Al Kasser, M (Author) Other; Al Mulla, A (Author) Other; Radaideh, G (Author) Other; Salustri, A (Author) Other

Journal

Title: European Journal of Heart Failure

Vol. 21

Pages: 921-929

ISSN: 1388-9842

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 58 Citations

Scopus - 57 Citations

Other information

Authenticus ID: P-00V-ZVE

DOI: 10.1002/ejhf.1459

Abstract (EN): Background Physicians' adherence to guideline-recommended therapy is associated with short-term clinical outcomes in heart failure (HF) with reduced ejection fraction (HFrEF). However, its impact on longer-term outcomes is poorly documented. Here, we present results from the 18-month follow-up of the QUALIFY registry. Methods and results Data at 18 months were available for 6118 ambulatory HFrEF patients from this international prospective observational survey. Adherence was measured as a continuous variable, ranging from 0 to 1, and was assessed for five classes of recommended HF medications and dosages. Most deaths were cardiovascular (CV) (228/394) and HF-related (191/394) and the same was true for unplanned hospitalizations (1175 CV and 861 HF-related hospitalizations, out of a total of 1541). According to univariable analysis, CV and HF deaths were significantly associated with physician adherence to guidelines. In multivariable analysis, HF death was associated with adherence level [subdistribution hazard ratio (SHR) 0.93, 95% confidence interval (CI) 0.87-0.99 per 0.1 unit adherence level increase; P = 0.034] as was composite of HF hospitalization or CV death (SHR 0.97, 95% CI 0.94-0.99 per 0.1 unit adherence level increase; P = 0.043), whereas unplanned all-cause, CV or HF hospitalizations were not (all-cause: SHR 0.99, 95% CI 0.9-1.02; CV: SHR 0.98, 95% CI 0.96-1.01; and HF: SHR 0.99, 95% CI 0.96-1.02 per 0.1 unit change in adherence score; P = 0.52, P = 0.2, and P = 0.4, respectively). Conclusion These results suggest that physicians' adherence to guideline-recommended HF therapies is associated with improved outcomes in HFrEF. Practical strategies should be established to improve physicians' adherence to guidelines.

Language: English

Type (Professor's evaluation): Dissemination

No. of pages: 9