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Novel Biomarkers for Evaluation of Endothelial Dysfunction

Title
Novel Biomarkers for Evaluation of Endothelial Dysfunction
Type
Article in International Scientific Journal
Year
2020
Authors
Leite, AR
(Author)
Other
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Borges Canha, M
(Author)
FMUP
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Cardoso, R
(Author)
FMUP
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Castro Ferreira, R
(Author)
FMUP
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Leite-Moreira AF
(Author)
FMUP
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Journal
The Journal is awaiting validation by the Administrative Services.
Title: ANGIOLOGYImported from Authenticus Search for Journal Publications
Vol. 71
Pages: 397-410
ISSN: 0003-3197
Publisher: SAGE Publications
Other information
Authenticus ID: P-00R-WQ5
Abstract (EN): Endothelial dysfunction is one of the earliest indicators of cardiovascular (CV) dysfunction, and its evaluation would be of considerable importance to stratify CV risk of many diseases and to assess the efficacy of atheroprotective treatments. Flow-mediated dilation is the most widely used method to study endothelial function. However, it is operator-dependent and can be influenced by physiological variations. Circulating biomarkers are a promising alternative. Due to the complexity of endothelial function, many of the biomarkers studied do not provide consistent information about the endothelium when measured alone. New circulating markers are being explored and some of them are thought to be suitable for the clinical setting. In this review, we focus on novel biomarkers of endothelial dysfunction, particularly endothelial microparticles, endocan, and endoglin, and discuss whether they fulfill the criteria to be applied in clinical practice.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 14
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