Review of methods for detecting glycemic disorders

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Bergman, M (Author) Other; Abdul Ghani, M (Author) Other; DeFronzo, RA (Author) Other; Manco, M (Author) Other; Sesti, G (Author) Other; Fiorentino, TV (Author) Other; Ceriello, A (Author) Other; Rhee, M (Author) Other; Phillips, LS (Author) Other; Chung, S (Author) Other; Cravalho, C (Author) Other; Jagannathan, R (Author) Other; Monnier, L (Author) Other; Colette, C (Author) Other; Owens, D (Author) Other; Bianchi, C (Author) Other; del Prato, S (Author) Other; Monteiro, M (Author) ICBAS; Neves, JS (Author) FMUP; Medina, JL (Author) Other; Macedo, MP (Author) Other; Ribeiro, RT (Author) Other; Raposo, JF (Author) Other; Dorcely, B (Author) Other; Ibrahim, N (Author) Other; Buysschaert, M (Author) Other

Journal

Title: Diabetes Research and Clinical Practice

Vol. 165

ISSN: 0168-8227

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 62 Citations

Scopus - 72 Citations

Other information

Authenticus ID: P-00S-AK4

DOI: 10.1016/j.diabres.2020.108233

Abstract (EN): Prediabetes (intermediate hyperglycemia) consists of two abnormalities, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) detected by a standardized 75-gram oral glucose tolerance test (OGTT). Individuals with isolated IGT or combined IFG and IGT have increased risk for developing type 2 diabetes (T2D) and cardiovascular disease (CVD). Diagnosing prediabetes early and accurately is critical in order to refer high-risk individuals for intensive lifestyle modification. However, there is currently no international consensus for diagnosing prediabetes with HbA1c or glucose measurements based upon American Diabetes Association (ADA) and the World Health Organization (WHO) criteria that identify different populations at risk for progressing to diabetes. Various caveats affecting the accuracy of interpreting the HbA1c including genetics complicate this further. This review describes established methods for detecting glucose disorders based upon glucose and HbA1c parameters as well as novel approaches including the 1-hour plasma glucose (1-h PG), glucose challenge test (GCT), shape of the glucose curve, genetics, continuous glucose monitoring (CGM), measures of insulin secretion and sensitivity, metabolomics, and ancillary tools such as fructosamine, glycated albumin (GA), 1,5-anhydroglucitol (1,5-AG). Of the approaches considered, the 1-h PG has considerable potential as a biomarker for detecting glucose disorders if confirmed by additional data including health economic analysis. Whether the 1-h OGTT is superior to genetics and omics in providing greater precision for individualized treatment requires further investigation. These methods will need to demonstrate substantially superiority to simpler tools for detecting glucose disorders to justify their cost and complexity. Published by Elsevier B.V.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 34