The Ratio Between Visceral and Subcutaneous Abdominal Fat Assessed by Computed Tomography Is an Independent Predictor of Mortality and Cardiac Events [El cociente entre la grasa abdominal visceral y la subcutánea evaluado por tomografía computarizada es un predictor independiente de mortalidad y eventos cardiacos]

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Ladeiras-Lopes R (Author) FMUP; Sampaio, F (Author) FMUP; Bettencourt, N (Author) FMUP; Fontes-Carvalho R (Author) FMUP; Ferreira, N (Author) Other; Leite-Moreira AF (Author) FMUP; Gama, V (Author) Other

Journal

Title: Revista Espanola de Cardiologia

Vol. 70

Pages: 331-337

ISSN: 0300-8932

Publisher: Elsevier

Indexing

Scopus - 63 Citations

Other information

Authenticus ID: P-00S-T7P

DOI: 10.1016/j.recesp.2016.09.006

Abstract (EN): Introduction and objectives Obesity is an important cardiovascular risk factor and the location of fat deposits seems to be an important determinant of its metabolic impact. Visceral adipose tissue (VAT) exerts a harmful effect on metabolic homeostasis, but few longitudinal studies have evaluated the prognostic impact of the ratio of VAT to subcutaneous adipose tissue (SAT). This study aimed to evaluate whether the VAT/SAT ratio was associated with all-cause mortality and cardiac events. Methods Registry-based retrospective cohort study. Eligible patients consisted of those without known heart disease referred to cardiac computed tomography (CT) angiography to evaluate suspected coronary artery disease (CAD). We included all patients with available information on VAT and SAT areas and coronary artery calcium (CAC) score. We assessed the combined endpoint of all-cause mortality, myocardial infarction or revascularization procedure at least 1 month after cardiac CT. Results The final population consisted of 713 participants (61% male; mean age, 57.7 ± 10.2 years) followed up for a median of 1.3 years. The combined endpoint occurred in 66 patients; these patients showed a higher VAT/SAT ratio (1.06 ± 0.74 vs 0.80 ± 0.52, P = .0001). The VAT/SAT ratio was an independent predictor of death and cardiac events (HR = 1.43; 95%CI, 1.03-1.99), irrespective of cardiovascular risk factors, CAC, and the presence of CAD. Conclusions The ratio between abdominal VAT/SAT was an independent predictor of death and coronary events, irrespective of cardiovascular risk factors, CAC, and the presence of CAD. This ratio is a CT-derived metric that may help to better identify patients with increased risk of death or cardiac events. Full English text available from: www.revespcardiol.org/en © 2016 Sociedad Española de Cardiología

Language: English

Type (Professor's evaluation): Scientific