Pituitary incidentalomas in paediatric age are different from those described in adulthood

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Souteiro, P (Author) Other; Maia, R (Author) Other; Santos Silva, R (Author) FMUP; Figueiredo, R (Author) Other; Costa, C (Author) FMUP; Belo, S (Author) Other; C Correia (Author) FMUP; Carvalho, Davide (Author) FMUP; Fontoura M (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: PITUITARY

Vol. 22

Pages: 124-128

ISSN: 1386-341X

Publisher: Springer

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 22 Citations

Other information

Authenticus ID: P-00Q-5PQ

DOI: 10.1007/s11102-019-00940-4

Abstract (EN): PurposeGuidelines on pituitary incidentalomas evaluation and management are limited to adults since there are no data on this matter in the paediatric population. We aim to analyse the morphologic characteristics, hormonal profile and follow-up of these lesions in children.MethodsWe have searched for pituitary incidentalomas in the neuroimaging reports and electronic medical records of the Paediatric Endocrinology Clinic of our centre. Patients with 18years-old or less were included.ResultsForty-one incidentalomas were identified, 25 of them (62.4%) in females. The mean age at diagnosis was 12.04.96 years-old. Headaches were the main reason that led to image acquisition (51.2%) and MRI was the imaging method that detected the majority of the incidentalomas (70.7%). The most prevalent lesion was pituitary hypertrophy (29.3%), which was mainly diagnosed in female adolescents (91.7%), followed by arachnoid cysts (17.1%), pituitary adenomas (14.6%) and Rathke's cleft cysts (12.2%). Most patients (90.2%) did not present clinical or laboratorial findings of hypopituitarism or hormonal hypersecretion. Four patients presented endocrine dysfunction: three had growth hormone deficiency and one had a central precocious puberty. Twenty-three patients (56.1%) underwent imagiological revaluation during a median follow-up time of 24.6months (interquartile range 5.07). None of them presented dimensional progression.Conclusions p id=Par4 To the best of our knowledge, this is the first series of pituitary incidentalomas in pediatric age. Comparing our series with those conducted in adults, we have observed a higher preponderance of pituitary hypertrophy over adenomas, a lower prevalence of hormonal hyper/hyposecretion and lower risk of dimensional progression during follow-up.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5