Metabolic risk factors in adolescent girls with type 1 diabetes

• Type: Article in International Scientific Journal
• Date: 2018

Authors

C Correia (Author) FMUP; Santos Silva, R (Author) FMUP; Pinheiro, M (Author) Other; Costa, C (Author) FMUP; Fontoura, M (Author) Other

Journal

Title: Journal of Pediatric Endocrinology and Metabolism

Vol. 31

Pages: 631-635

ISSN: 0334-018X

Publisher: Walter De Gruyter

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-00R-AA6

DOI: 10.1515/jpem-2018-0053

Abstract (EN): The incidence of pediatric metabolic syndrome (MS) has progressively increased. The incidence of type 1 diabetes mellitus (T1DM) has also increased. Thus, some children and adolescents with T1DM exhibit MS parameters. The aim of the study was to evaluate the presence of MS parameters in female adolescents with T1DM based on their nutritional status. We evaluated 44 adolescents with T1DM (consecutive non-randomized sample) aged between 14 and 18 years, who were on intensive therapy with insulin. Patients were subdivided according to their body mass index (BMI). Variables evaluated include: Age, age at diagnosis, weight, height, BMI, abdominal circumference, blood pressure, glycated hemoglobin (HbA1c), abdominal and pelvic ultrasound and lipoprotein profile. Gynecological history data were also collected. Lipid profile changes were identified in 32% of overweight or obese girls and in 23% of those with an adequate weight. Hypertension (HT) was observed in 19% of overweight or obese girls and in 14% of those with a BMI¿85th percentile (Pc). The only statistically significant difference between the groups was the presence of abdominal adiposity. All other features, including the presence of dyslipidemia, HT, abdominal adiposity, non-alcoholic steatohepatitis (NASH) and polycystic ovarian syndrome (PCOS), were present in both groups. Although being overweight and/or obese aggravates the risk of cardiovascular disease, MS is already present in many young adolescents with T1DM of normal weight. It is necessary that MS risk factors are routinely evaluated in all diabetic adolescents, including those with an adequate BMI. © 2018 Walter de Gruyter GmbH, Berlin/Boston.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5