Antiangiogenic and Antioxidant In Vitro Properties of Hydroethanolic Extract from acai (Euterpe oleracea) Dietary Powder Supplement

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Costa, R (Author) Other; Azevedo, D (Author) Other; Barata, P (Author) Other; soares, r (Author) FMUP; Luis F Guido (Author) FCUP; Carvalho, DO (Author) FFUP

Journal

Title: Molecules

Vol. 26 No. 17

Final page: 2011

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00T-QPE

DOI: 10.3390/molecules26072011

Abstract (EN): The Euterpe oleracea fruit (acai) is a promising source of polyphenols with health-promoting properties. To our knowledge, few studies have focused on the influence of acai phytochemicals on angiogenesis, with a significant impact on cancer. This study aimed at investigating the phytochemical profile of a purple acai hydroethanolic extract (AHE) obtained from a commercial dietary powder supplement by high-performance liquid chromatography coupled to diode array detection and electrospray ionization mass spectrometry, and evaluate its in vitro effects on distinct angiogenic steps during vessel growth and on oxidative markers in human microvascular endothelial cells (HMEC-1). The phenolic profile of AHE revealed the presence of significant levels of anthocyanins, mainly cyanidin-3-O-rutinoside, and other flavonoids with promising health effects. The in vitro studies demonstrated that AHE exerts antiangiogenic activity with no cytotoxic effect. The AHE was able to decrease HMEC-1 migration and invasion potential, as well as to inhibit the formation of capillary-like structures. Additionally, AHE increased antioxidant defenses by upregulating superoxide dismutase and catalase enzymatic activities, accompanied by a reduction in the production of reactive oxygen species. These data bring new insights into the potential application of angiogenic inhibitors present in AHE on the development of novel therapeutic approaches for angiogenesis-dependent diseases.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17